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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12ZincUniRule annotation1
Metal bindingi15ZincUniRule annotation1
Metal bindingi146ZincUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMGIL350054:G1G8L-2201-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:Mflv_2165
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001971 – 2841D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST284

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_2165

Structurei

3D structure databases

ProteinModelPortaliA4T907
SMRiA4T907
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KZ5 Bacteria
COG2120 LUCA
HOGENOMiHOG000241173
KOiK15525
OMAiKFYWTVT
OrthoDBiPOG091H08W5

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
HAMAPiMF_01696 MshB, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
IPR017810 Mycothiol_biosynthesis_MshB
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit
TIGRFAMsiTIGR03445 mycothiol_MshB, 1 hit

Sequencei

Sequence statusi: Complete.

A4T907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPRLLFVH AHPDDETLTT GATIAHYTAR GAEVQVITCT LGEEGEVIGD
60 70 80 90 100
RWAQLAVDHA DQLGGYRIGE LTAALAALGV DRPRYLGGAG RWRDSGMEGT
110 120 130 140 150
PARRRERFVD GDVAEQTAVL AAAIDELRPH VVVTYDPNGG YGHPDHIHTH
160 170 180 190 200
RLTTAAVEAA AWQVPKFYWT VTSDSALRTG IAALTDVPDG WVTLTADDLP
210 220 230 240 250
LVGFTDDTID AALDLGAHSA ARVAAMHAHQ TQITVAPDGR SFALSNDIAL
260 270 280
PVDATEYYVL ARGEAGERDA RGWETDLLAG LNLR
Length:284
Mass (Da):30,478
Last modified:May 15, 2007 - v1
Checksum:iAC3840F0EB095AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP44643.1
RefSeqiWP_011893053.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP44643; ABP44643; Mflv_2165
KEGGimgi:Mflv_2165

Similar proteinsi

Entry informationi

Entry nameiMSHB_MYCGI
AccessioniPrimary (citable) accession number: A4T907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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