Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGIL350054:G1G8L-2334-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Mflv_2296
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000000232 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000762221 – 550Arginine--tRNA ligaseAdd BLAST550

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi350054.Mflv_2296

Structurei

3D structure databases

ProteinModelPortaliA4T8M4
SMRiA4T8M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 140"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247214
KOiK01887
OMAiNKPLHLG
OrthoDBiPOG091H01RF

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 2 hits
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A4T8M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPADLAQLL KATAAAVLAE HGLDSAALPD TVTVERPRNP EHGDYATNLA
60 70 80 90 100
LQLGKKVGAN PRELAGWLAE ALAASDGIAA ADVAGPGFVN LRIEASAQNV
110 120 130 140 150
MVSNVLSAGA DYGHSAVLAG KKVNLEFVSA NPTGPIHIGG TRWAAVGDAL
160 170 180 190 200
GRLLTTQGAA VTREYYFNDH GAQIDRFSNS LIAAAKGEPA PEDGYAGTYI
210 220 230 240 250
ADIASQVVAK EPGVLDQPDD RMRETFRAIG VNLMFDHIKE SLHEFGTDFD
260 270 280 290 300
VYTHEDSMHT SGRVEQAIDK LRETGFAYEK DGAVWLRTTD FGDDKDRVVI
310 320 330 340 350
KSDGKPAYIA GDLAYFLDKR KRGFDLCIYM LGADHHGYIA RLKASAAALG
360 370 380 390 400
DDPDTVEVLI GQMVNLVRDG QPVRMSKRAG TVITLDDLVE AIGVDAARYS
410 420 430 440 450
LIRSSVDTPI DIDLELWSSA SNENPVYYVQ YAHARLSALA RNAAELGIAP
460 470 480 490 500
DTAHLDLLTH DKEGVLIRNI GEFPRILATA AELREPHRVS RYLEDLAGDY
510 520 530 540 550
HRFYDACRVL PQGDEAPGDL HAARLALCAA TRQVIANGLD ILGVSAPERM
Length:550
Mass (Da):59,204
Last modified:May 15, 2007 - v1
Checksum:iA47BAA39AC88EA57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP44774.1
RefSeqiWP_011893179.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP44774; ABP44774; Mflv_2296
KEGGimgi:Mflv_2296

Similar proteinsi

Entry informationi

Entry nameiSYR_MYCGI
AccessioniPrimary (citable) accession number: A4T8M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health