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A4T8L8 (A4T8L8_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384
Gene names
Name:thrB HAMAP MF_00384
Ordered Locus Names:Mflv_2300
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384 SAAS SAAS006203

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384 SAAS SAAS006203

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP MF_00384 SAAS SAAS006203.

Sequence similarities

Belongs to the GHMP kinase family. RuleBase RU004209

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding96 – 10611ATP By similarity HAMAP MF_00384

Sequences

Sequence LengthMass (Da)Tools
A4T8L8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 7390956078E70506

FASTA31532,300
        10         20         30         40         50         60 
MVTRTLPPGV SATAEVAASS ANLGPGFDSL GLAVGLYDEI SVETTESGLV VEVEGEGAGQ 

        70         80         90        100        110        120 
VPLDESHLVV RAIQRGLREN GIDAPGLIVR CRNRIPHSRG LGSSAAAVVG GLAAASGLAM 

       130        140        150        160        170        180 
QADSTPMSAE RLVQVSSEFE GHPDNAAAAV LGGAVVSWTE DRGDGPRYAA VQIRLHPAIT 

       190        200        210        220        230        240 
VFAAIPQVRS STAETRVLLP EHVSHADASF NVSRAALLIV ALTERPDLLL AATEDALHQS 

       250        260        270        280        290        300 
QRAPAMPASA EYLAVLRRCG VAGVLSGAGP SVLALSTEAE LPVEAAEFGN RNGFEIVRMS 

       310 
VGHGVTWSSG VAAKS

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP44778.1.
RefSeqYP_001133566.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4T8L8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4T8L8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000024316; EBMYCP00000023978; EBMYCG00000024311.
GeneID4973622.
GenomeReviewsGene locus Mflv_2300 in contig CP000656_GR.
KEGGmgi:Mflv_2300.
PATRIC18032717. VBIMycGil17082_2352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
GeneTreeEBGT00050000016145.
HOGENOMHBG646290.
OMADRLHQPY.
PhylomeDBA4T8L8.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4T8L8_MYCGI
AccessionPrimary (citable) accession number: A4T8L8
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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