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A4T7I8 (A4T7I8_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:Mflv_1634
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site141For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2551Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4011Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4601Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4631Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A4T7I8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: EF6D629580FE64AB

FASTA51154,441
        10         20         30         40         50         60 
MTAEQLENEP REECGVFGVW APGEEVSKLT YYGLYALQHR GQEAAGIAVA DGSQVLVFKD 

        70         80         90        100        110        120 
LGLVSQVFDE QTLAAMPGHV AVGHCRYSTT GSTTWENAQP VFRNTAAGTG VALGHNGNLV 

       130        140        150        160        170        180 
NTAELAARAR DEGLMNDRGA ATATTDSDIL GALLAHGAAD SSLEQAALEL LPTVRGAFCL 

       190        200        210        220        230        240 
TFMDENTLYA ARDPYGVRPL SLGRLDRGWV VASETAALDI VGASFVRDIE PGELLAIDAD 

       250        260        270        280        290        300 
GVRSTRFANP TPKGCVFEYV YLARPDSTIV GRSVHATRVD IGRRLAREKP IDADLVIGVP 

       310        320        330        340        350        360 
ESGTPAAVGY AQESGIPFGQ GLMKNAYVGR TFIQPSQTIR QLGIRLKLNP LKEVIRGKRL 

       370        380        390        400        410        420 
IVVDDSIVRG NTQRALIRML REAGAVEVHV RIASPPVKWP CFYGIDFATP AELIANAASN 

       430        440        450        460        470        480 
SADDDGMLDG VRRAIGADTL AYISREGMIA ATEQPATRLC SACFDGDYPI ELPGETALGK 

       490        500        510 
NVIEHMLATA ARTGLPVSPA DNDNASALRR P

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP44116.1.
RefSeqYP_001132904.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4T7I8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4T7I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000024569; EBMYCP00000024231; EBMYCG00000024564.
GeneID4972960.
GenomeReviewsGene locus Mflv_1634 in contig CP000656_GR.
KEGGmgi:Mflv_1634.
PATRIC18031333. VBIMycGil17082_1670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0034.
GeneTreeEBGT00050000016850.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4T7I8_MYCGI
AccessionPrimary (citable) accession number: A4T7I8
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info