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A4T6W8

- G6PI_MYCGI

UniProt

A4T6W8 - G6PI_MYCGI

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Protein
Glucose-6-phosphate isomerase
Gene
pgi, Mflv_1857
Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donor By similarity
Active sitei384 – 3841 By similarity
Active sitei510 – 5101 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-1875-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:Mflv_1857
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000232: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomeraseUniRule annotation
PRO_1000081243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_1857.

Structurei

3D structure databases

ProteinModelPortaliA4T6W8.
SMRiA4T6W8. Positions 4-546.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OMAiMIALTHY.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4T6W8-1 [UniParc]FASTAAdd to Basket

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MGTDITATSE WQALARHRDE IGETNLRQLF ADDAARGLRF AVTVGGLYID    50
YSKHRVTAET LNLLVDVARA AGLETKRDAM FSGEHINTSE DRAVLHTALR 100
LPRDAALTVD GQDVVADVHE VLDRMGDFTD RLRSGDWLGA TGERITTVVN 150
IGIGGSDLGP VMVDQALRHY ADAGISARFV SNVDPADLVA KLAGLNPATT 200
LFVIASKTFS TLETLTNATA ARRWLIEALG EDAVSKHFVA VSTNAKLVAE 250
FGIDTDNMFG FWDWVGGRYS VDSAIGLSVM AVIGRERFAE FLAGFHLIDE 300
HFRTAPLEAN APVLLGLIGL WYNNFFGAET RAVLPYSNDL ARFAAYLQQL 350
TMESNGKSVQ ADGTPVSTAT GEIFWGEPGT NGQHAFYQLL HQGTRLVPAD 400
FIGFSEPTDD LPTADGTGSM HDLLMSNFFA QTQVLAFGKT ADEISAEGTS 450
PDVVPHKVMP GNRPTTSILA TKLTPSVVGQ LIALYEHQVF VEGVIWGIDS 500
FDQWGVELGK TQAKALLPVL TDAEPPAAQS DSSTDALVRR YRSERGRTA 549
Length:549
Mass (Da):59,375
Last modified:May 15, 2007 - v1
Checksum:i0CAF911F567217AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000656 Genomic DNA. Translation: ABP44337.1.
RefSeqiWP_011892748.1. NC_009338.1.
YP_001133125.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP44337; ABP44337; Mflv_1857.
GeneIDi4973181.
KEGGimgi:Mflv_1857.
PATRICi18031803. VBIMycGil17082_1899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000656 Genomic DNA. Translation: ABP44337.1 .
RefSeqi WP_011892748.1. NC_009338.1.
YP_001133125.1. NC_009338.1.

3D structure databases

ProteinModelPortali A4T6W8.
SMRi A4T6W8. Positions 4-546.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350054.Mflv_1857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP44337 ; ABP44337 ; Mflv_1857 .
GeneIDi 4973181.
KEGGi mgi:Mflv_1857.
PATRICi 18031803. VBIMycGil17082_1899.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261371.
KOi K01810.
OMAi MIALTHY.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
UPA00138 .
BioCyci MGIL350054:GHK8-1875-MONOMER.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PYR-GCK.

Entry informationi

Entry nameiG6PI_MYCGI
AccessioniPrimary (citable) accession number: A4T6W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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