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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei353Proton donorUniRule annotation1
Active sitei384UniRule annotation1
Active sitei510UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Mflv_1857
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000812431 – 549Glucose-6-phosphate isomeraseAdd BLAST549

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_1857

Structurei

3D structure databases

ProteinModelPortaliA4T6W8
SMRiA4T6W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261371
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A4T6W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTDITATSE WQALARHRDE IGETNLRQLF ADDAARGLRF AVTVGGLYID
60 70 80 90 100
YSKHRVTAET LNLLVDVARA AGLETKRDAM FSGEHINTSE DRAVLHTALR
110 120 130 140 150
LPRDAALTVD GQDVVADVHE VLDRMGDFTD RLRSGDWLGA TGERITTVVN
160 170 180 190 200
IGIGGSDLGP VMVDQALRHY ADAGISARFV SNVDPADLVA KLAGLNPATT
210 220 230 240 250
LFVIASKTFS TLETLTNATA ARRWLIEALG EDAVSKHFVA VSTNAKLVAE
260 270 280 290 300
FGIDTDNMFG FWDWVGGRYS VDSAIGLSVM AVIGRERFAE FLAGFHLIDE
310 320 330 340 350
HFRTAPLEAN APVLLGLIGL WYNNFFGAET RAVLPYSNDL ARFAAYLQQL
360 370 380 390 400
TMESNGKSVQ ADGTPVSTAT GEIFWGEPGT NGQHAFYQLL HQGTRLVPAD
410 420 430 440 450
FIGFSEPTDD LPTADGTGSM HDLLMSNFFA QTQVLAFGKT ADEISAEGTS
460 470 480 490 500
PDVVPHKVMP GNRPTTSILA TKLTPSVVGQ LIALYEHQVF VEGVIWGIDS
510 520 530 540
FDQWGVELGK TQAKALLPVL TDAEPPAAQS DSSTDALVRR YRSERGRTA
Length:549
Mass (Da):59,375
Last modified:May 15, 2007 - v1
Checksum:i0CAF911F567217AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP44337.1
RefSeqiWP_011892748.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP44337; ABP44337; Mflv_1857
KEGGimgi:Mflv_1857

Similar proteinsi

Entry informationi

Entry nameiG6PI_MYCGI
AccessioniPrimary (citable) accession number: A4T6W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health