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A4T5S9 (A4T5S9_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acsA HAMAP MF_01123
Ordered Locus Names:Mflv_1380
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5261 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6191N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
A4T5S9 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: D846FB8E317FC18B

FASTA65371,937
        10         20         30         40         50         60 
MTETHVDIPS SYPPDPGFAE NANATEALYE QADADRLEFW AEQARRLAWE TPFDEVLDWS 

        70         80         90        100        110        120 
EAPFAKWFVG GTLNVAYNCV DRHVEAGNGD RVAIHWVGEP VEHSRDITYA ELKDEVCRAA 

       130        140        150        160        170        180 
NALTNLGLTA GDRVAIYMPM VPEAIIAMLA CARLGAMHSV VFAGFSASAL KARIEDAQAK 

       190        200        210        220        230        240 
LVITTDGQYR RGSAVSLKTG VDEAIDGLGE DSPVEHVLVV RRTGIDTPWT PDRDLWWDET 

       250        260        270        280        290        300 
VPEADTEHTP EAFDSEQPLF LLYTSGTTGK PKGIVHTSGG YLTQTAYTHH NVFDLKPESD 

       310        320        330        340        350        360 
VYWCTADIGW VTGHSYIVYG PLANGATQVV YEGTPASPTE HRHFEIIEKY GVTIYYTAPT 

       370        380        390        400        410        420 
LVRTFMRWGR QIPAEHDLSS LRLLGSVGEP INPEAWRWYR MAFGKDKTPI VDTWWQTETG 

       430        440        450        460        470        480 
AIMISPLPGV THCKPGSAMR ALPGISAKVV DDDGNELERS PDHGEHATGY LVLDQPWPAM 

       490        500        510        520        530        540 
LRGIWGDPER FKETYWSRFA EKGWYFAGDG ARIGSDGEIW VLGRIDDVMN ISGHRISTAE 

       550        560        570        580        590        600 
VESALVGHSG VAEAAVVGAT DEHTGQAICA FVILKSSAHG GEENMIDELR AEVAKEISPI 

       610        620        630        640        650 
AKPREIHVVP ELPKTRSGKI MRRLLRDVAE GRELGDTSTL VDPSVFEAIR ASK

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP43862.1.
RefSeqYP_001132650.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4T5S9.
SMRA4T5S9. Positions 16-651.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4T5S9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000026315; EBMYCP00000025977; EBMYCG00000026310.
GeneID4972706.
GenomeReviewsGene locus Mflv_1380 in contig CP000656_GR.
KEGGmgi:Mflv_1380.
PATRIC18030808. VBIMycGil17082_1410.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
GeneTreeEBGT00050000015141.
HOGENOMHBG547964.
OMAHEERIHA.
PhylomeDBA4T5S9.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4T5S9_MYCGI
AccessionPrimary (citable) accession number: A4T5S9
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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