A4T4T8 (A4T4T8_MYCGI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377
Ordered Locus Names:	Mflv_0827

Organism

Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]

Taxonomic identifier

350054 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377 RuleBase RU000577
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377 RuleBase RU004227

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377 RuleBase RU000577
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 RuleBase RU000577 DNA-binding HAMAP MF_00377 RuleBase RU000577 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	193 – 200	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	A4T4T8 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 010E50E67DBD3EF6	FASTA	492	55,169
	10 20 30 40 50 60 MSLTTDPDPP FVAIWDNVVT ELNGTGGTQN GSLTPQQRAW LKLVRPLVIT EGFALLSVPT 70 80 90 100 110 120 PFVQNEIERH LREPIVAALS RQLGQRVELG VRIADPAADD VNDGAAVTAA SVPADTDEVD 130 140 150 160 170 180 DDLAARASAE ESWPSYFNRA KTSAEDDSLS VNLNRRYTFE TFVIGASNRF AHAASLAIAE 190 200 210 220 230 240 APARAYNPLF IWGESGLGKT HLLHAAGNYA QRLFPGMRVK YVSTEEFTND FINSLRDDRR 250 260 270 280 290 300 ASFKRTYRDI DVLLVDDIQF IEGKDGIQEE FFHTFNTLHN ANKQIVISSD RPPKQLATLE 310 320 330 340 350 360 DRLRTRFEWG LITDVQPPEL ETRIAILRKK AQMDRLDVPD DVLELIASRI ERNIRELEGA 370 380 390 400 410 420 LIRVTAFASL NKTSIDKSLA EIVLRDLISD PGTMQISTAA IMAATAEYFE TSVDELRGPG 430 440 450 460 470 480 KTRALAQSRQ IAMYLCRELT DLSLPKIGQA FGRDHTTVMY AEKKIRAEMA ERREVFDHVK 490 ELTTRIRQRS KR

References

[1]

"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PYR-GCK.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000656 Genomic DNA. Translation: ABP43311.1.
RefSeq	YP_001132099.1. NC_009338.1.
3D structure databases
ProteinModelPortal	A4T4T8.
ModBase	Search...
Protein-protein interaction databases
STRING	A4T4T8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000025100; EBMYCP00000024762; EBMYCG00000025095.
GeneID	4972155.
GenomeReviews	Gene locus Mflv_0827 in contig CP000656_GR.
KEGG	mgi:Mflv_0827.
PATRIC	18029665. VBIMycGil17082_0844.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
GeneTree	EBGT00050000017320.
HOGENOM	HBG695666.
OMA	DEVAFLI.
PhylomeDB	A4T4T8.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4T4T8_MYCGI

Accession

Primary (citable) accession number: A4T4T8

Entry history

Integrated into UniProtKB/TrEMBL:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)