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A4T4R2

- SYL_MYCGI

UniProt

A4T4R2 - SYL_MYCGI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei725 – 7251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGIL350054:GHK8-857-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mflv_0853
    OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
    Taxonomic identifieri350054 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000232: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Leucine--tRNA ligasePRO_0000334774Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi350054.Mflv_0853.

    Structurei

    3D structure databases

    ProteinModelPortaliA4T4R2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi68 – 7912"HIGH" regionAdd
    BLAST
    Motifi722 – 7265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4T4R2-1 [UniParc]FASTAAdd to Basket

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    MTETPIAPLD DTPRFRYTAV LAGEIERAWQ QQWADSGTFH VDNPVGSLAP    50
    ADGSAVPADK MFVQDMFPYP SGEGLHVGHP LGYIATDVYA RYYRMTGRNV 100
    LHALGFDAFG LPAEQYAIQT GTHPRTRTEA NIVNFRRQLG RLGLGHDSRR 150
    SFATTDVDYY KWTQWIFLQI FNAWFDTDQN RARPIRELIA EFEAGTRQVG 200
    DGRSWADLDA GARADLVDAH RLVYLADSVV NWCPGLGTVL ANEEVTADGR 250
    SERGNFPVFR KRLRQWMMRI TAYSDRLLED LDVLDWPDKV KTMQRNWIGR 300
    STGAEVQFST AAGDIEVFTT RPDTLFGATY MVLAPEHDLV DRLVASAWPD 350
    GTDARWTFGA ATPAEAVAAY RAGIAAKSDL ERQENKTKTG VFLGAYATNP 400
    ANGQQVPVFI ADYVLAGYGT GAIMAVPSGD QRDWDFATEF GLPIVEVVAG 450
    GDVTVEAYSG DGTMVNSGFL DGMDVATAKQ AMTERLVADG RGRARVEYKL 500
    RDWLFARQRY WGEPFPVVYD SEGRAHGLPE GMLPVELPDV PDYSPVSFDP 550
    DDAGSEPSPP LGKVTDWVNV DLDLGDGLKP YTRDTNVMPQ WAGSSWYELR 600
    YTDPYNSEAL CAKENEAYWM GPRPAEHGPD DPGGVDLYVG GVEHAVLHLL 650
    YSRFWHKVLY DLGHVSSREP YRRLVNQGYI QAFAYTDSRG SYVPAAEVIE 700
    RDGKFVWPGP DGETEVNQEF GKIGKSLKNS VSPDEICDNY GADTLRVYEM 750
    SMGPLEASRP WATKDVVGAY RFLQRVWRLV VDENTGETLA TEDALDDDTL 800
    RLLHRTIAGT ADDYASLRNN TAAAKLIEYT NHLTKQSVTA RAALEPLVLM 850
    VAPLAPHLAE ELWKRLGHEG SLAHGPFPLA DERYLVEDTV EYPVQVNGKV 900
    RGRVTVPADA PADAVEAAAL AEEKVVAFLD GRTPKKVIVV AGRLVNVVV 949
    Length:949
    Mass (Da):105,013
    Last modified:May 15, 2007 - v1
    Checksum:i84E6A5DB25C6AF7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000656 Genomic DNA. Translation: ABP43337.1.
    RefSeqiYP_001132125.1. NC_009338.1.

    Genome annotation databases

    EnsemblBacteriaiABP43337; ABP43337; Mflv_0853.
    GeneIDi4972181.
    KEGGimgi:Mflv_0853.
    PATRICi18029721. VBIMycGil17082_0872.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000656 Genomic DNA. Translation: ABP43337.1 .
    RefSeqi YP_001132125.1. NC_009338.1.

    3D structure databases

    ProteinModelPortali A4T4R2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350054.Mflv_0853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP43337 ; ABP43337 ; Mflv_0853 .
    GeneIDi 4972181.
    KEGGi mgi:Mflv_0853.
    PATRICi 18029721. VBIMycGil17082_0872.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MGIL350054:GHK8-857-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PYR-GCK.

    Entry informationi

    Entry nameiSYL_MYCGI
    AccessioniPrimary (citable) accession number: A4T4R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3