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A4T4R2

- SYL_MYCGI

UniProt

A4T4R2 - SYL_MYCGI

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei725 – 7251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mflv_0853
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000232: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Leucine--tRNA ligasePRO_0000334774Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_0853.

Structurei

3D structure databases

ProteinModelPortaliA4T4R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi68 – 7912"HIGH" regionAdd
BLAST
Motifi722 – 7265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4T4R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTETPIAPLD DTPRFRYTAV LAGEIERAWQ QQWADSGTFH VDNPVGSLAP
60 70 80 90 100
ADGSAVPADK MFVQDMFPYP SGEGLHVGHP LGYIATDVYA RYYRMTGRNV
110 120 130 140 150
LHALGFDAFG LPAEQYAIQT GTHPRTRTEA NIVNFRRQLG RLGLGHDSRR
160 170 180 190 200
SFATTDVDYY KWTQWIFLQI FNAWFDTDQN RARPIRELIA EFEAGTRQVG
210 220 230 240 250
DGRSWADLDA GARADLVDAH RLVYLADSVV NWCPGLGTVL ANEEVTADGR
260 270 280 290 300
SERGNFPVFR KRLRQWMMRI TAYSDRLLED LDVLDWPDKV KTMQRNWIGR
310 320 330 340 350
STGAEVQFST AAGDIEVFTT RPDTLFGATY MVLAPEHDLV DRLVASAWPD
360 370 380 390 400
GTDARWTFGA ATPAEAVAAY RAGIAAKSDL ERQENKTKTG VFLGAYATNP
410 420 430 440 450
ANGQQVPVFI ADYVLAGYGT GAIMAVPSGD QRDWDFATEF GLPIVEVVAG
460 470 480 490 500
GDVTVEAYSG DGTMVNSGFL DGMDVATAKQ AMTERLVADG RGRARVEYKL
510 520 530 540 550
RDWLFARQRY WGEPFPVVYD SEGRAHGLPE GMLPVELPDV PDYSPVSFDP
560 570 580 590 600
DDAGSEPSPP LGKVTDWVNV DLDLGDGLKP YTRDTNVMPQ WAGSSWYELR
610 620 630 640 650
YTDPYNSEAL CAKENEAYWM GPRPAEHGPD DPGGVDLYVG GVEHAVLHLL
660 670 680 690 700
YSRFWHKVLY DLGHVSSREP YRRLVNQGYI QAFAYTDSRG SYVPAAEVIE
710 720 730 740 750
RDGKFVWPGP DGETEVNQEF GKIGKSLKNS VSPDEICDNY GADTLRVYEM
760 770 780 790 800
SMGPLEASRP WATKDVVGAY RFLQRVWRLV VDENTGETLA TEDALDDDTL
810 820 830 840 850
RLLHRTIAGT ADDYASLRNN TAAAKLIEYT NHLTKQSVTA RAALEPLVLM
860 870 880 890 900
VAPLAPHLAE ELWKRLGHEG SLAHGPFPLA DERYLVEDTV EYPVQVNGKV
910 920 930 940
RGRVTVPADA PADAVEAAAL AEEKVVAFLD GRTPKKVIVV AGRLVNVVV
Length:949
Mass (Da):105,013
Last modified:May 15, 2007 - v1
Checksum:i84E6A5DB25C6AF7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP43337.1.
RefSeqiYP_001132125.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP43337; ABP43337; Mflv_0853.
GeneIDi4972181.
KEGGimgi:Mflv_0853.
PATRICi18029721. VBIMycGil17082_0872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP43337.1 .
RefSeqi YP_001132125.1. NC_009338.1.

3D structure databases

ProteinModelPortali A4T4R2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 350054.Mflv_0853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP43337 ; ABP43337 ; Mflv_0853 .
GeneIDi 4972181.
KEGGi mgi:Mflv_0853.
PATRICi 18029721. VBIMycGil17082_0872.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MGIL350054:GHK8-857-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PYR-GCK.

Entry informationi

Entry nameiSYL_MYCGI
AccessioniPrimary (citable) accession number: A4T4R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3