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A4T3P0 (A4T3P0_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase 1 HAMAP MF_00012
Short name=DAD 1 HAMAP MF_00012
EC=4.2.1.9 HAMAP MF_00012
Gene names
Name:ilvD1 HAMAP MF_00012
Ordered Locus Names:Mflv_0486
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP MF_00012

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family. HAMAP MF_00012

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1511Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012
Metal binding2281Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012

Sequences

Sequence LengthMass (Da)Tools
A4T3P0 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: FFDCFFD31BFEE8CE

FASTA58961,980
        10         20         30         40         50         60 
MWPMNRRAHN HPMPSDSRSH SLRASGSSVD IKPRSRDVTD GLERTAARGM LRAVGMTDDD 

        70         80         90        100        110        120 
WVKPQIGVGS SWNEITPCNM SLQRLAQAVK GGVHEAGGYP LEFGTISVSD GISMGHEGMH 

       130        140        150        160        170        180 
FSLVSREVIA DSVETVVQAE RLDGTVLLAG CDKSIPGMLM AAARLDLASV FFYNGSIMPG 

       190        200        210        220        230        240 
VAKLTDGSEK EVTIIDAFEA VGACARGLMS REDVDIIERA ICPGEGACGG MYTANTMASA 

       250        260        270        280        290        300 
AEALGMSLPG SASPVAIDKR RDDFARRSGE AVVEMLRRGI TARDILTKEA FENAIAVVMA 

       310        320        330        340        350        360 
FGGSTNAVLH LLAIAWEAQV ELTLADFTRI GQKVPHLADV KPFGAYVMKH VDEIGGVPVV 

       370        380        390        400        410        420 
MRALLDAGLL HGDCLTVTGQ TMAENLAHIE PPDPDGKVLR AMNNPIHPTG GITILHGSLA 

       430        440        450        460        470        480 
PEGAVVKSAG FDSDVFEGTA RVFERERAAL DALEDGTITH GDVVVIRYEG PKGGPGMREM 

       490        500        510        520        530        540 
LAITGAIKGA GLGKDVLLMT DGRFSGGTTG LCVGHIAPEA VDGGPIAFVR DGDRIRLDVA 

       550        560        570        580 
NGTLDILVDE AEFESRKAGF EPLPPVYTTG VLAKYTKLVG SAAVGAVCS

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP42979.1.
RefSeqYP_001131767.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4T3P0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4T3P0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000027457; EBMYCP00000027119; EBMYCG00000027452.
GeneID4971561.
GenomeReviewsGene locus Mflv_0486 in contig CP000656_GR.
KEGGmgi:Mflv_0486.
PATRIC18028980. VBIMycGil17082_0504.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG146415.
GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
PhylomeDBA4T3P0.
ProtClustDBPRK00911.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4T3P0_MYCGI
AccessionPrimary (citable) accession number: A4T3P0
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info