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Protein

Dihydrolipoyl dehydrogenase

Gene

Mflv_0114

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Mflv_0114Imported
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))Imported
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_0114.

Structurei

3D structure databases

ProteinModelPortaliA4T2Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 327FAD/NAD-binding_domInterPro annotationAdd BLAST324
Domaini348 – 455Pyr_redox_dimInterPro annotationAdd BLAST108

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTMSEAVM.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer_sf.
IPR006258. Lipoamide_DH.
IPR001100. Pyr_nuc-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
PIRSFiPIRSF000350. Mercury_reductase_MerA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00076. PYRIDINE_REDOX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A4T2Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHYDVVVLG AGPGGYVAAI RAAQLGLSTA IVEPKYWGGV CLNVGCIPSK
60 70 80 90 100
ALLRNAELAH VFHKDAKTFG ISGDVSFDYG AAFDRSRKVA DGRVAGVHFL
110 120 130 140 150
MKKNKITEVH GYGRFTGPNS IEVEPTGDGE EGPVKLEFDN AIIATGSSTR
160 170 180 190 200
LVPGTSLSEN VVTYEKQILT RELPGSIIIA GAGAIGMEFA YVLKNYGVDV
210 220 230 240 250
TIVEFLPRAL PNEDAEVSKE IEKQYKKLGV KILTGTKVEK IEDDGKQVTV
260 270 280 290 300
TVSKNDKTEE LKADKVMQAI GFAPNVEGFG LDKAGVELTD RKAIGIDDYM
310 320 330 340 350
RTNVPHIYAI GDVTAKLQLA HVAEAMGVVA AETIAGADTL PFEDYRMMPR
360 370 380 390 400
ATFCQPQVAS FGLTEQQAKD EGYDVVVAKF PFTANGKAHG LGDPTGFVKL
410 420 430 440 450
IADKKHLELL GGHLIGPDVA ELLPELTLAQ KWDLTANELA RNVHTHPTLS
460
EAMQECFHGL VGHMINF
Length:467
Mass (Da):50,264
Last modified:May 15, 2007 - v1
Checksum:iCC2976FF09303CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP42609.1.
RefSeqiWP_011891116.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP42609; ABP42609; Mflv_0114.
KEGGimgi:Mflv_0114.

Similar proteinsi

Entry informationi

Entry nameiA4T2Z6_MYCGI
AccessioniPrimary (citable) accession number: A4T2Z6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported