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Protein

Superoxide dismutase [Cu-Zn]

Gene

Mflv_0172

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-172-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mflv_0172Imported
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))Imported
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 PotentialImportedAdd
BLAST
Chaini31 – 236206 PotentialImportedPRO_5000235897Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_0172.

Structurei

3D structure databases

ProteinModelPortaliA4T2T9.
SMRiA4T2T9. Positions 66-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4T2T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSVAAATL FAVPALALSA CSPPGEVPSD SPGTTPSVWT GSPSPSAEAG
60 70 80 90 100
EHGAGHGGGS GQASGETLTA ELNLADGTTV ANAEIVFSDG YATVTVETTG
110 120 130 140 150
EGDLTPGFHG MHIHQVGKCE PNSVAPTGGA PGNFNSAGGH LQVGGNTGHP
160 170 180 190 200
ASGDLTSLQV REDGSAKVVT TTDAFTAEDL TGDAGTAIII HEKADNFANI
210 220 230
PPERYQQVDG APPPDQTTLA TGDAGARVAC GVITGS
Length:236
Mass (Da):23,240
Last modified:May 15, 2007 - v1
Checksum:i79BF8C99DF7E2AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP42667.1.
RefSeqiWP_011891174.1. NC_009338.1.
YP_001131455.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP42667; ABP42667; Mflv_0172.
KEGGimgi:Mflv_0172.
PATRICi18028326. VBIMycGil17082_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP42667.1.
RefSeqiWP_011891174.1. NC_009338.1.
YP_001131455.1. NC_009338.1.

3D structure databases

ProteinModelPortaliA4T2T9.
SMRiA4T2T9. Positions 66-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350054.Mflv_0172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP42667; ABP42667; Mflv_0172.
KEGGimgi:Mflv_0172.
PATRICi18028326. VBIMycGil17082_0177.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-172-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PYR-GCKImported.

Entry informationi

Entry nameiA4T2T9_MYCGI
AccessioniPrimary (citable) accession number: A4T2T9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.