A4T2N4 (IOLG_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Mflv_2598

Organism

Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]

Taxonomic identifier

350054 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352575

Sequences

	Sequence		Length	Mass (Da)
	A4T2N4 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 826EE1AF7486A261	FASTA	349	37,047
	10 20 30 40 50 60 MTDLRIAVLG VGVMGADHVA RITSRISGAR VAVVNDHLVE KAEQLAASIP GCSAVADPLD 70 80 90 100 110 120 AIADADVDAV VLATPGGTHE EQLLACLDQR KPVMCEKPLT TDVSTSLEIA RREADLGRPL 130 140 150 160 170 180 IQVGFMRRFD DEYVRLKALL DGGELGNPLM MHCVHRNPGV PAYFDSSLIV KDSLVHEVDI 190 200 210 220 230 240 TRYLFGEEIA SVQIIKPTSN PGAPNGVVDP QIAILRTVSG RHVDVELFVT TGVAYEVRTE 250 260 270 280 290 300 VVGEHGSAII GLDVGLIRKK GPGSWGGTLT PGFRERFGPA YDTEIQRWVD AVHSGTNVCG 310 320 330 340 PTAWDGYAAA AVCAAGVESL ETGLPVDVQL ADEVTSPSPQ GVRESDGCR

References

[1]

"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PYR-GCK.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000656 Genomic DNA. Translation: ABP45075.1.
RefSeq	YP_001133863.1. NC_009338.1.
3D structure databases
ProteinModelPortal	A4T2N4.
ModBase	Search...
Protein-protein interaction databases
STRING	A4T2N4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000025659; EBMYCP00000025321; EBMYCG00000025654.
GeneID	4973919.
GenomeReviews	Gene locus Mflv_2598 in contig CP000656_GR.
KEGG	mgi:Mflv_2598.
PATRIC	18033343. VBIMycGil17082_2656.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
GeneTree	EBGT00050000017284.
HOGENOM	HBG612336.
OMA	RTEVVGE.
ProtClustDB	CLSK956652.
Enzyme and pathway databases
BioCyc	MGIL350054:MFLV_2598-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_MYCGI

Accession

Primary (citable) accession number: A4T2N4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program