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A4T250 (A4T250_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:Mflv_2781
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length929 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
A4T250 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 9FD6931B2F79857D

FASTA929103,690
        10         20         30         40         50         60 
MTTEFVRQDL AQNSSSTGEP DRVRVIREGV ASYLPDIDPE ETGEWLESFD DLLERSGPAR 

        70         80         90        100        110        120 
ARYLMLRLLE RAGEQRVAIP ALTSTDYVNT IPTELEPWFP GDEDVERRYR AWIRWNAAIM 

       130        140        150        160        170        180 
VHRAQRPGVG VGGHISTYAS SAALYEVGFN HFFRGKSHPG GGDQVFIQGH ASPGIYARAF 

       190        200        210        220        230        240 
LEGRLTTDQL DGFRQEHSHA GGGLPSYPHP RLMPDFWEFP TVSMGLGPMN AIYQARFNHY 

       250        260        270        280        290        300 
LHDRDIKDTS KQHVWAFLGD GEMDEPESRG LIQVAANEGL DNLTFVVNCN LQRLDGPVRG 

       310        320        330        340        350        360 
NGKIIQELES FFRGAGWNVI KVVWGREWDA LLHADRDGAL VNLMNTTPDG DYQTYKANDG 

       370        380        390        400        410        420 
SYVRDHFFGR DPRTKALVEP MTDAEIWNLK RGGHDYRKVY AAYHAAMEHK GQPTVILAKT 

       430        440        450        460        470        480 
IKGYTLGKHF EGRNATHQMK KLALQDLKDF RDVQRIPVSD SQLEENPYLP PYYHPGPEAP 

       490        500        510        520        530        540 
EIRYMLDRRR ALGGFLPERR TKTKALTLPG RDTYKALKKG SGKQEVATTM ATVRTFKELL 

       550        560        570        580        590        600 
RDKNIGWRIV PIIPDEARTF GMDSWFPSLK IYNRNGQLYT AVDAELMLAY KESEVGQILH 

       610        620        630        640        650        660 
EGINEAGSTA SFTAVGTSYA THNEPMIPIY IFYSMFGFQR TGDGLWAAAD QMARGFVLGA 

       670        680        690        700        710        720 
TAGRTTLVGE GLQHADGHSL LLAATNPAVV SYDPAFAFEI AYIIESGLQR MYGDNPENVY 

       730        740        750        760        770        780 
FYMTIYNEPY VQPAEPEGID VEGLLRGMYR YQAAPQKKSN SAQILVSGVS MPSALKAAEM 

       790        800        810        820        830        840 
LAEEWDVSAD VWSVTSWGEL NREGVAIEKE RLRHPDREVA TPYVTEALAG AEGPVVAVSD 

       850        860        870        880        890        900 
WMRAVPEQIR PWVPGTYVTL GTDGFGFSDT RPAARRYYNT DAESIVVAVL EGLARDGNID 

       910        920 
ISAAVDAARR YEIDDVMAAP EQTSDPGVA

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP45258.1.
RefSeqYP_001134046.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4T250.
SMRA4T250. Positions 85-920.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4T250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000023777; EBMYCP00000023439; EBMYCG00000023772.
GeneID4974102.
GenomeReviewsGene locus Mflv_2781 in contig CP000656_GR.
KEGGmgi:Mflv_2781.
PATRIC18033719. VBIMycGil17082_2842.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
GeneTreeEBGT00050000016271.
HOGENOMHBG289271.
OMAFRQEKSH.
PhylomeDBA4T250.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4T250_MYCGI
AccessionPrimary (citable) accession number: A4T250
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info