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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA)
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62S-adenosyl-L-methionineUniRule annotation1
Binding sitei80S-adenosyl-L-methionineUniRule annotation1
Binding sitei117S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processMenaquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMGIL350054:G1G8L-5350-MONOMER
UniPathwayiUPA00079; UER00169

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:Mflv_5258
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000882851 – 228Demethylmenaquinone methyltransferaseAdd BLAST228

Proteomic databases

PRIDEiA4T183

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_5258

Structurei

3D structure databases

ProteinModelPortaliA4T183
SMRiA4T183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 101S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDZ Bacteria
COG2226 LUCA
HOGENOMiHOG000249464
KOiK03183
OMAiVRNFENL
OrthoDBiPOG091H01LK

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4T183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRASLEKNP HEVASMFDGV ARRYDLTNTV LSLGQDRFWR RATREALQLS
60 70 80 90 100
PADKVLDLAA GTAVSTVELA SSGAWCVAAD FSVGMLAAGA SRRVPKVAGD
110 120 130 140 150
ATRLPFDDGV FDAVTISFGL RNVVDFSAGL REMARVTRPG GRLVVCEFST
160 170 180 190 200
PTNGLFSTVY KEYLMKALPA MATAVSSNPD AYVYLAESIR AWPDQRALAR
210 220
RIEAAGWSDV RWRNLTGGIV ALHAATKP
Length:228
Mass (Da):24,640
Last modified:May 15, 2007 - v1
Checksum:iF16EAB67E96A538A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP47722.1
RefSeqiWP_011896078.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP47722; ABP47722; Mflv_5258
KEGGimgi:Mflv_5258

Similar proteinsi

Entry informationi

Entry nameiMENG_MYCGI
AccessioniPrimary (citable) accession number: A4T183
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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