A4T070 (PTH_POLSQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	Pnuc_1922

Organism

Polynucleobacter sp. (strain QLW-P1DMWA-1) [Complete proteome] [HAMAP]

Taxonomic identifier

312153 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Polynucleobacter

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_1000092968

Sequences

	Sequence		Length	Mass (Da)
	A4T070 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: C906C164D638199E	FASTA	196	21,793
	10 20 30 40 50 60 MTKLIVGLGN PGEEHTEDRH NAGFWFLDVL AKQLNSRFES EKRFHGKVAK AKWEGEDLFL 70 80 90 100 110 120 LKPSTYMNLS GQSVGALCRF HKITPAEILV VQDELDLKPG TARLKLGGGT GGHNGLKDIQ 130 140 150 160 170 180 AHLSTPEYWR LRLGIGHPRD LAGDGRPMDV ADYVLRRPQL AEQKMIDASI ENGLQILPLF 190 LKGDTQTAMM ELHSKA

References

[1]

"Complete sequence of Polynucleobacter sp. QLW-P1DMWA-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Poeckl M., Wu Q.L., Hahn M., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QLW-P1DMWA-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000655 Genomic DNA. Translation: ABP35134.1.
RefSeq	YP_001156698.1. NC_009379.1.
3D structure databases
ProteinModelPortal	A4T070.
ModBase	Search...
Protein-protein interaction databases
STRING	A4T070.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5052205.
GenomeReviews	Gene locus Pnuc_1922 in contig CP000655_GR.
KEGG	pnu:Pnuc_1922.
PATRIC	22968369. VBIPolNec12025_1988.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HBG610927.
OMA	SHAGHNG.
PhylomeDB	A4T070.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	PSP312153:PNUC_1922-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. False negative. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_POLSQ

Accession

Primary (citable) accession number: A4T070

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program