A4T032 (ARGC_POLSQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Pnuc_1884

Organism

Polynucleobacter sp. (strain QLW-P1DMWA-1) [Complete proteome] [HAMAP]

Taxonomic identifier

312153 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Polynucleobacter

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000076736
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4T032 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: E2560AA8910F57B0	FASTA	352	37,777
	10 20 30 40 50 60 MIKVGIVGGT GYTGVELLRL LAQHPEVELT AITSRTEAGM PVAEMFPSLR GRVALKFTTP 70 80 90 100 110 120 DEAKLNECDV VFFATPHGVA MAQAKELLAN GVKVLDLAAD FRLKDVKEFA KWYGMEHNCP 130 140 150 160 170 180 EILAEAVYGL PEINRDAIKK ARVVGLAGCY PTSVQLGLAP LLSPKSTGGK HLIDGTHIIS 190 200 210 220 230 240 DSKSGTSGAG RKAEIGTLLS EASDNFKAYS VKGHRHLPEI EQGLKAIAGH DQIGLTFVPH 250 260 270 280 290 300 LTPMIRGIHS TLYVRLTEAG KDVDYQKLYE NFYKDEPFVD VMPAGSHPET RSVRGSNGIR 310 320 330 340 350 IAIHRPGGGD TLVILVVEDN LVKGASGQGV QCMNLMFGLP ETTGLTQIAV SP

References

[1]

"Complete sequence of Polynucleobacter sp. QLW-P1DMWA-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Poeckl M., Wu Q.L., Hahn M., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QLW-P1DMWA-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000655 Genomic DNA. Translation: ABP35096.1.
RefSeq	YP_001156660.1. NC_009379.1.
3D structure databases
ProteinModelPortal	A4T032.
ModBase	Search...
Protein-protein interaction databases
STRING	A4T032.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5053948.
GenomeReviews	Gene locus Pnuc_1884 in contig CP000655_GR.
KEGG	pnu:Pnuc_1884.
PATRIC	22968291. VBIPolNec12025_1950.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	A4T032.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	PSP312153:PNUC_1884-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_POLSQ

Accession

Primary (citable) accession number: A4T032

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program