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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93L-glutamineUniRule annotation1
Binding sitei238L-glutamineUniRule annotation1
Binding sitei257ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 58ATPUniRule annotation3
Nucleotide bindingi62 – 68ATPUniRule annotation7
Nucleotide bindingi292 – 293ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Short name:
GlnRSUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:Pnuc_1722
OrganismiPolynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
Taxonomic identifieri312153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi
  • UP000000231 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000954971 – 590Glutamine--tRNA ligaseAdd BLAST590

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi312153.Pnuc_1722.

Structurei

3D structure databases

SMRiA4SZM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 65"HIGH" regionUniRule annotationAdd BLAST11
Motifi299 – 303"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CX6. Bacteria.
COG0008. LUCA.
HOGENOMiHOG000259232.
KOiK01886.
OMAiVTHSICT.
OrthoDBiPOG091H00G9.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPiMF_00126. Gln_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SZM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDSKPTKS AAGAIAEPSN FLRQIIDHDL ASGAFAQRTN LAGEAIPSII
60 70 80 90 100
TRFPPEPNGY LHIGHAKSIC LNFGLAADYN NQSGGARCNM RLDDTNPVKE
110 120 130 140 150
DVEYADSILD AVKWLGFDWG THLYHASDYF DRLYEFAEIL IQNSKAYVDS
160 170 180 190 200
QSADDIHTNR GNFGQVGKNS PYRERTPDEN LQLFREMRDG KFKDGEHVLR
210 220 230 240 250
LKIDMAHPNI VMRDPVVYRI RHTDHHRTGS KWCIYPLYDF THCISDALEN
260 270 280 290 300
VSHSICTLEF ENNRPLYDWI VNSLKELGVF KDPVPHQYEF ARLNLTYTIT
310 320 330 340 350
SKRKLLQLVE EQHVEGWDDP RMPTIVGIRR RGYTPESIRL FCERIGVSKA
360 370 380 390 400
DSWIDMSTLD QALRDDLEAR APRATAVLKP LKLVVENFDA AHSEACSAPR
410 420 430 440 450
HPHHPEWGNR EFNFTKELWI EADDFMQEPV KGFFRLYPPI GDQPGSRVRL
460 470 480 490 500
RHGFVVECTD FETDAKGNIT QVNVNYFPDS KSGTPGSNNY KVKGNIHWIS
510 520 530 540 550
AAEAIPAEVR LYDHLFTDPH PDSGDKNFLD TINPHSKETI KAYLEPCMKD
560 570 580 590
VKPEDRFQFE RHGYFVADQN DSAPGKPVFN RTVGLKDSWK
Length:590
Mass (Da):67,427
Last modified:May 15, 2007 - v1
Checksum:iDDEDA6ADF43DB4E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000655 Genomic DNA. Translation: ABP34935.1.
RefSeqiWP_011903558.1. NC_009379.1.

Genome annotation databases

EnsemblBacteriaiABP34935; ABP34935; Pnuc_1722.
GeneIDi31482111.
KEGGipnu:Pnuc_1722.

Similar proteinsi

Entry informationi

Entry nameiSYQ_POLAQ
AccessioniPrimary (citable) accession number: A4SZM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 15, 2007
Last modified: August 30, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families