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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase I (Pnuc_0295), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei159May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Pnuc_1703
OrganismiPolynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
Taxonomic identifieri312153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi
  • UP000000231 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003720331 – 272GTP cyclohydrolase FolE2Add BLAST272

Interactioni

Protein-protein interaction databases

STRINGi312153.Pnuc_1703.

Structurei

3D structure databases

SMRiA4SZK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiPOG091H0MIO.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiView protein in InterPro
IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERiPTHR36445:SF2. PTHR36445:SF2. 1 hit.
PfamiView protein in Pfam
PF02649. GCHY-1. 1 hit.
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SZK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPAFLKASA MPDVQSSRDE RALPIEQVGI RGVRHPLMIR SNTGNFPSVG
60 70 80 90 100
NFEMDVALPA HVKGTHMSRF MALLQKQDEA IDSTTVVALV RDMLPLLDAK
110 120 130 140 150
EGHVQFTYTH FVKKAAPVSG VESLMDYEVT WMATAKQNDA GSVEVELGLR
160 170 180 190 200
AQVPVMSLCP CSKEISEFGA HNQRSHVTMT VVLDTQTKMT VEDLVSAAER
210 220 230 240 250
EASSELWGLL KRPDEKWVTE RSYSNPKFVE DLVRDVAGRL KADTRIQSFV
260 270
VDAENFESIH NHSAFARISH KK
Length:272
Mass (Da):30,294
Last modified:May 5, 2009 - v2
Checksum:i05B8FBEFE86CD2A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000655 Genomic DNA. Translation: ABP34916.1.

Genome annotation databases

EnsemblBacteriaiABP34916; ABP34916; Pnuc_1703.
KEGGipnu:Pnuc_1703.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGCH4_POLAQ
AccessioniPrimary (citable) accession number: A4SZK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 7, 2017
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families