Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Polynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei21UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Pnuc_0662
OrganismiPolynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Taxonomic identifieri312153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi
  • UP000000231 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000873561 – 190Peptide methionine sulfoxide reductase MsrAAdd BLAST190

Interactioni

Protein-protein interaction databases

STRINGi312153.Pnuc_0662.

Structurei

3D structure databases

ProteinModelPortaliA4SWL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXP. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263863.
KOiK07304.
OMAiYCMAVVA.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SWL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEITDKNLP TLERATLGGG CFWCLEAVYQ QIQGVKSVVS GYAGGARPNP
60 70 80 90 100
SYESVCTGAT GHAEIVDIEF DPKVVSFRDL LEIFFVIHNP TTLNYQGNDH
110 120 130 140 150
GTQYRSVIYT HSDEQAKIAN EVVQELEDSK IYADPVVTQI ESAPTIYPAE
160 170 180 190
DYHQNYFQQH PHQGYCAAVV APKLAKFRAK FKSLIAPQYA
Length:190
Mass (Da):21,162
Last modified:May 15, 2007 - v1
Checksum:iF96D92EC14D4E2B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000655 Genomic DNA. Translation: ABP33880.1.
RefSeqiWP_011902505.1. NC_009379.1.

Genome annotation databases

EnsemblBacteriaiABP33880; ABP33880; Pnuc_0662.
KEGGipnu:Pnuc_0662.
PATRICi22965717. VBIPolNec12025_0687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000655 Genomic DNA. Translation: ABP33880.1.
RefSeqiWP_011902505.1. NC_009379.1.

3D structure databases

ProteinModelPortaliA4SWL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi312153.Pnuc_0662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP33880; ABP33880; Pnuc_0662.
KEGGipnu:Pnuc_0662.
PATRICi22965717. VBIPolNec12025_0687.

Phylogenomic databases

eggNOGiENOG4107QXP. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263863.
KOiK07304.
OMAiYCMAVVA.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_POLSQ
AccessioniPrimary (citable) accession number: A4SWL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.