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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei21UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciPNEC312153:G1G8K-691-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Pnuc_0662
OrganismiPolynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
Taxonomic identifieri312153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
Proteomesi
  • UP000000231 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000873561 – 190Peptide methionine sulfoxide reductase MsrAAdd BLAST190

Interactioni

Protein-protein interaction databases

STRINGi312153.Pnuc_0662

Structurei

3D structure databases

ProteinModelPortaliA4SWL6
SMRiA4SWL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXP Bacteria
COG0225 LUCA
HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

A4SWL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEITDKNLP TLERATLGGG CFWCLEAVYQ QIQGVKSVVS GYAGGARPNP
60 70 80 90 100
SYESVCTGAT GHAEIVDIEF DPKVVSFRDL LEIFFVIHNP TTLNYQGNDH
110 120 130 140 150
GTQYRSVIYT HSDEQAKIAN EVVQELEDSK IYADPVVTQI ESAPTIYPAE
160 170 180 190
DYHQNYFQQH PHQGYCAAVV APKLAKFRAK FKSLIAPQYA
Length:190
Mass (Da):21,162
Last modified:May 15, 2007 - v1
Checksum:iF96D92EC14D4E2B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000655 Genomic DNA Translation: ABP33880.1
RefSeqiWP_011902505.1, NC_009379.1

Genome annotation databases

EnsemblBacteriaiABP33880; ABP33880; Pnuc_0662
GeneIDi31481019
KEGGipnu:Pnuc_0662

Similar proteinsi

Entry informationi

Entry nameiMSRA_POLAQ
AccessioniPrimary (citable) accession number: A4SWL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health