A4SW52 (A4SW52_POLSQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase 2 HAMAP MF_01023
EC=2.6.1.9 HAMAP MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase 2 HAMAP MF_01023

Gene names

Name:	hisC2 HAMAP MF_01023
Ordered Locus Names:	Pnuc_0496

Organism

Polynucleobacter sp. (strain QLW-P1DMWA-1) [Complete proteome] [HAMAP] EMBL ABP33716.1

Taxonomic identifier

312153 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Polynucleobacter

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP MF_01023
Ligand	Pyridoxal phosphate HAMAP MF_01023
Molecular function	Aminotransferase HAMAP MF_01023 EMBL ABP33716.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	231	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01023

Sequences

	Sequence		Length	Mass (Da)
	A4SW52 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 0D2F241C755458C4	FASTA	374	40,224
	10 20 30 40 50 60 MTSKIGLKHI HAIAPYVGGR PISEVAREYG LDETKIVKLA SNENPLGMPK SAQEAMLKAA 70 80 90 100 110 120 SDLGRYPDSN GFELKNVLAS RLGVPTDWIT LGNGSNDILE LAARAVAQAG DEVIFSKHAF 130 140 150 160 170 180 AVYPLATQAV GAKAVEVDAT AMYGHNLPAM LTAIKAAGDK AKLVFVANPN NPTGSYLTAK 190 200 210 220 230 240 EIEDFLMAVP SNVVVVLDEA YNEYLNLEQR YDAIAWVKRF ANMILSRSFS KAYGLAGLRI 250 260 270 280 290 300 GYGVAQPHLT DLLNRIRQPF NVNSLAQAAA IAAFQDQAFL QQGFELNLAG YGQLTTAFDE 310 320 330 340 350 360 LGLRYLPSAG NFVLVKVGED DQAGARINLA LLKRGIIVRP VGNYGLPQWL RISIGLPEEN 370 AAFIGALKAI LAPQ

References

[1]

"Complete sequence of Polynucleobacter sp. QLW-P1DMWA-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Poeckl M., Wu Q.L., Hahn M., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: QLW-P1DMWA-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000655 Genomic DNA. Translation: ABP33716.1.
RefSeq	YP_001155280.1. NC_009379.1.
3D structure databases
ProteinModelPortal	A4SW52.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SW52.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5052894.
GenomeReviews	Gene locus Pnuc_0496 in contig CP000655_GR.
KEGG	pnu:Pnuc_0496.
PATRIC	22965367. VBIPolNec12025_0514.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	ENPLGMP.
ProtClustDB	PRK02731.
Enzyme and pathway databases
BioCyc	PSP312153:PNUC_0496-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4SW52_POLSQ

Accession

Primary (citable) accession number: A4SW52

Entry history

Integrated into UniProtKB/TrEMBL:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)