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A4SVD9

- SYL_POLSQ

UniProt

A4SVD9 - SYL_POLSQ

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Protein
Leucine--tRNA ligase
Gene
leuS, Pnuc_0232
Organism
Polynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei648 – 6481ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPNEC312153:GH50-243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Pnuc_0232
OrganismiPolynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Taxonomic identifieri312153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000000231: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Leucine--tRNA ligaseUniRule annotation
PRO_1000074838Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312153.Pnuc_0232.

Structurei

3D structure databases

ProteinModelPortaliA4SVD9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi645 – 6495"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SVD9-1 [UniParc]FASTAAdd to Basket

« Hide

MSKDYDHRGI EAAAQADWER TQVYRVTENA VNASGKKKPK YYACSMLPYP    50
SGKLHMGHVR NYTINDVMAR QLRMQGYNVL MPMGWDAFGM PAENAAIQNK 100
VPPAKWTYDN IAYMKKQMAA MGLAIDWSRE VATCSPDYYR WNQWLFLKML 150
EKGVAYRKTQ VVNWDPIDQT VLANEQVIDG RGWRSGALVE KREIPGYYFN 200
ITAYAEQLLS GLDGLGWPER VKTMQQNWIG KSRGVRFAFK HEIADAHGNF 250
IQDGLLYVFT TRADTIMGVT FCAVAAEHPL ASKAAENNPT LAAFIEKCKT 300
GSVIEADLAT QEKEGMFTGL YVTHPLTNES VPVWVGNYVL MSYGDGAVMG 350
VPAHDERDFA FALKYELPIK QVIALKDESP MFNGTHWQDW YAQKENVVCF 400
NSGKFDGLSH EEAVNTVASD LEKMGIGELK TTYRLRDWGI SRQRYWGTPI 450
PIIHCGDEGN PGCGAVPVPE ADLPVVLPED CVPDGSGNPL NKRADFLNVK 500
CPQCGKPARR ETDTMDTFVD SSWYFMRYTG PDATSMVDGR NEYWMPMDQY 550
IGGIEHAILH LLYARFWTKV MRDLDLITFD EPFQNLLTQG MVLNETYYSE 600
EASGKKTWLN PLDVELDLDE KGRPQGAKLK GDSSGTPVII GGVEKMSKSK 650
NNGVDPQALI DQYGADTARL FVMFAAPPEQ QLEWSGAGVD GASRFLRRVW 700
MYSSSQASAI KDAQDALPST LNDAEKELRR EVHAILKQAN FDYQRRQYNT 750
VVSAAMKMLN VLEPIKLGQD SPISASVLRE CLSILLRVLY PVVPHLTHVL 800
WKDMGYSENF GSLLDAPWPT VDETALIQTE ITLMLQINGK LRGELKVPAD 850
ASKEQIEAIA LQSEPATKAL NGGAPKKVIV VPGRLINIVA 890
Length:890
Mass (Da):99,554
Last modified:May 15, 2007 - v1
Checksum:iB9ED38A7A3BF2954
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000655 Genomic DNA. Translation: ABP33453.1.
RefSeqiYP_001155017.1. NC_009379.1.

Genome annotation databases

EnsemblBacteriaiABP33453; ABP33453; Pnuc_0232.
GeneIDi5053383.
KEGGipnu:Pnuc_0232.
PATRICi22964813. VBIPolNec12025_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000655 Genomic DNA. Translation: ABP33453.1 .
RefSeqi YP_001155017.1. NC_009379.1.

3D structure databases

ProteinModelPortali A4SVD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312153.Pnuc_0232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP33453 ; ABP33453 ; Pnuc_0232 .
GeneIDi 5053383.
KEGGi pnu:Pnuc_0232.
PATRICi 22964813. VBIPolNec12025_0239.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PNEC312153:GH50-243-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18221 / CIP 109841 / QLW-P1DMWA-1.

Entry informationi

Entry nameiSYL_POLSQ
AccessioniPrimary (citable) accession number: A4SVD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi