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A4SVD9

- SYL_POLSQ

UniProt

A4SVD9 - SYL_POLSQ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Polynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei648 – 6481ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPNEC312153:GH50-243-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pnuc_0232
    OrganismiPolynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
    Taxonomic identifieri312153 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
    ProteomesiUP000000231: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 890890Leucine--tRNA ligasePRO_1000074838Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi312153.Pnuc_0232.

    Structurei

    3D structure databases

    ProteinModelPortaliA4SVD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi645 – 6495"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4SVD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKDYDHRGI EAAAQADWER TQVYRVTENA VNASGKKKPK YYACSMLPYP    50
    SGKLHMGHVR NYTINDVMAR QLRMQGYNVL MPMGWDAFGM PAENAAIQNK 100
    VPPAKWTYDN IAYMKKQMAA MGLAIDWSRE VATCSPDYYR WNQWLFLKML 150
    EKGVAYRKTQ VVNWDPIDQT VLANEQVIDG RGWRSGALVE KREIPGYYFN 200
    ITAYAEQLLS GLDGLGWPER VKTMQQNWIG KSRGVRFAFK HEIADAHGNF 250
    IQDGLLYVFT TRADTIMGVT FCAVAAEHPL ASKAAENNPT LAAFIEKCKT 300
    GSVIEADLAT QEKEGMFTGL YVTHPLTNES VPVWVGNYVL MSYGDGAVMG 350
    VPAHDERDFA FALKYELPIK QVIALKDESP MFNGTHWQDW YAQKENVVCF 400
    NSGKFDGLSH EEAVNTVASD LEKMGIGELK TTYRLRDWGI SRQRYWGTPI 450
    PIIHCGDEGN PGCGAVPVPE ADLPVVLPED CVPDGSGNPL NKRADFLNVK 500
    CPQCGKPARR ETDTMDTFVD SSWYFMRYTG PDATSMVDGR NEYWMPMDQY 550
    IGGIEHAILH LLYARFWTKV MRDLDLITFD EPFQNLLTQG MVLNETYYSE 600
    EASGKKTWLN PLDVELDLDE KGRPQGAKLK GDSSGTPVII GGVEKMSKSK 650
    NNGVDPQALI DQYGADTARL FVMFAAPPEQ QLEWSGAGVD GASRFLRRVW 700
    MYSSSQASAI KDAQDALPST LNDAEKELRR EVHAILKQAN FDYQRRQYNT 750
    VVSAAMKMLN VLEPIKLGQD SPISASVLRE CLSILLRVLY PVVPHLTHVL 800
    WKDMGYSENF GSLLDAPWPT VDETALIQTE ITLMLQINGK LRGELKVPAD 850
    ASKEQIEAIA LQSEPATKAL NGGAPKKVIV VPGRLINIVA 890
    Length:890
    Mass (Da):99,554
    Last modified:May 15, 2007 - v1
    Checksum:iB9ED38A7A3BF2954
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000655 Genomic DNA. Translation: ABP33453.1.
    RefSeqiYP_001155017.1. NC_009379.1.

    Genome annotation databases

    EnsemblBacteriaiABP33453; ABP33453; Pnuc_0232.
    GeneIDi5053383.
    KEGGipnu:Pnuc_0232.
    PATRICi22964813. VBIPolNec12025_0239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000655 Genomic DNA. Translation: ABP33453.1 .
    RefSeqi YP_001155017.1. NC_009379.1.

    3D structure databases

    ProteinModelPortali A4SVD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 312153.Pnuc_0232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP33453 ; ABP33453 ; Pnuc_0232 .
    GeneIDi 5053383.
    KEGGi pnu:Pnuc_0232.
    PATRICi 22964813. VBIPolNec12025_0239.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PNEC312153:GH50-243-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 18221 / CIP 109841 / QLW-P1DMWA-1.

    Entry informationi

    Entry nameiSYL_POLSQ
    AccessioniPrimary (citable) accession number: A4SVD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3