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A4SVD9

- SYL_POLSQ

UniProt

A4SVD9 - SYL_POLSQ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Polynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei648 – 6481ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPNEC312153:GH50-243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pnuc_0232
OrganismiPolynucleobacter necessarius subsp. asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Taxonomic identifieri312153 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaePolynucleobacter
ProteomesiUP000000231: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Leucine--tRNA ligasePRO_1000074838Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi312153.Pnuc_0232.

Structurei

3D structure databases

ProteinModelPortaliA4SVD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi645 – 6495"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SVD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKDYDHRGI EAAAQADWER TQVYRVTENA VNASGKKKPK YYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDVMAR QLRMQGYNVL MPMGWDAFGM PAENAAIQNK
110 120 130 140 150
VPPAKWTYDN IAYMKKQMAA MGLAIDWSRE VATCSPDYYR WNQWLFLKML
160 170 180 190 200
EKGVAYRKTQ VVNWDPIDQT VLANEQVIDG RGWRSGALVE KREIPGYYFN
210 220 230 240 250
ITAYAEQLLS GLDGLGWPER VKTMQQNWIG KSRGVRFAFK HEIADAHGNF
260 270 280 290 300
IQDGLLYVFT TRADTIMGVT FCAVAAEHPL ASKAAENNPT LAAFIEKCKT
310 320 330 340 350
GSVIEADLAT QEKEGMFTGL YVTHPLTNES VPVWVGNYVL MSYGDGAVMG
360 370 380 390 400
VPAHDERDFA FALKYELPIK QVIALKDESP MFNGTHWQDW YAQKENVVCF
410 420 430 440 450
NSGKFDGLSH EEAVNTVASD LEKMGIGELK TTYRLRDWGI SRQRYWGTPI
460 470 480 490 500
PIIHCGDEGN PGCGAVPVPE ADLPVVLPED CVPDGSGNPL NKRADFLNVK
510 520 530 540 550
CPQCGKPARR ETDTMDTFVD SSWYFMRYTG PDATSMVDGR NEYWMPMDQY
560 570 580 590 600
IGGIEHAILH LLYARFWTKV MRDLDLITFD EPFQNLLTQG MVLNETYYSE
610 620 630 640 650
EASGKKTWLN PLDVELDLDE KGRPQGAKLK GDSSGTPVII GGVEKMSKSK
660 670 680 690 700
NNGVDPQALI DQYGADTARL FVMFAAPPEQ QLEWSGAGVD GASRFLRRVW
710 720 730 740 750
MYSSSQASAI KDAQDALPST LNDAEKELRR EVHAILKQAN FDYQRRQYNT
760 770 780 790 800
VVSAAMKMLN VLEPIKLGQD SPISASVLRE CLSILLRVLY PVVPHLTHVL
810 820 830 840 850
WKDMGYSENF GSLLDAPWPT VDETALIQTE ITLMLQINGK LRGELKVPAD
860 870 880 890
ASKEQIEAIA LQSEPATKAL NGGAPKKVIV VPGRLINIVA
Length:890
Mass (Da):99,554
Last modified:May 15, 2007 - v1
Checksum:iB9ED38A7A3BF2954
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000655 Genomic DNA. Translation: ABP33453.1.
RefSeqiYP_001155017.1. NC_009379.1.

Genome annotation databases

EnsemblBacteriaiABP33453; ABP33453; Pnuc_0232.
GeneIDi5053383.
KEGGipnu:Pnuc_0232.
PATRICi22964813. VBIPolNec12025_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000655 Genomic DNA. Translation: ABP33453.1 .
RefSeqi YP_001155017.1. NC_009379.1.

3D structure databases

ProteinModelPortali A4SVD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 312153.Pnuc_0232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP33453 ; ABP33453 ; Pnuc_0232 .
GeneIDi 5053383.
KEGGi pnu:Pnuc_0232.
PATRICi 22964813. VBIPolNec12025_0239.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PNEC312153:GH50-243-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18221 / CIP 109841 / QLW-P1DMWA-1.

Entry informationi

Entry nameiSYL_POLSQ
AccessioniPrimary (citable) accession number: A4SVD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3