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A4STJ8

- GPPA_AERS4

UniProt

A4STJ8 - GPPA_AERS4

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro
    3. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciASAL382245:GJJN-4282-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:ASA_4296
    OrganismiAeromonas salmonicida (strain A449)
    Taxonomic identifieri382245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000225: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314492Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382245.ASA_4296.

    Structurei

    3D structure databases

    ProteinModelPortaliA4STJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    Gene3Di1.10.3210.10. 1 hit.
    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR006674. HD_domain.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4STJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR    50
    LSRAAMERGW DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE 100
    RVLNHSIEII SGEEEAKTIY EGVSWTSAGE GNRLVIDIGG ASTELVIGEH 150
    SEAKLLNSLH MGCVTWLNNH FGDGELSEAR FAQAIAAAKA VLEKVAEDYC 200
    VLGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG QAIACGRLDR 250
    LQLEGLAAER LTVFPSGLAI LIAIFETLNI ESMTLAGGAL REGLIYGLLG 300
    NNHDCDARDR TADSLISCYQ LDKEHAERVR DTAIEAFNQL QPAWRLSKRY 350
    GRPILRYAAL LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL 400
    LFNQRDEFKL ETLEKQGAVT GRQAIRLARI LRISLILCMR RTQGTVPNFT 450
    LQAEEEALTL TLPKGWMDEH YLRASELRLE VERQQKMGWP TRLLEA 496
    Length:496
    Mass (Da):55,128
    Last modified:May 15, 2007 - v1
    Checksum:iDFAEF0947CFD692D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000644 Genomic DNA. Translation: ABO92220.1.
    RefSeqiWP_005320675.1. NC_009348.1.
    YP_001143968.1. NC_009348.1.

    Genome annotation databases

    EnsemblBacteriaiABO92220; ABO92220; ASA_4296.
    GeneIDi4997051.
    KEGGiasa:ASA_4296.
    PATRICi20795054. VBIAerSal2987_4261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000644 Genomic DNA. Translation: ABO92220.1 .
    RefSeqi WP_005320675.1. NC_009348.1.
    YP_001143968.1. NC_009348.1.

    3D structure databases

    ProteinModelPortali A4STJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382245.ASA_4296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO92220 ; ABO92220 ; ASA_4296 .
    GeneIDi 4997051.
    KEGGi asa:ASA_4296.
    PATRICi 20795054. VBIAerSal2987_4261.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci ASAL382245:GJJN-4282-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3210.10. 1 hit.
    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR006674. HD_domain.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
      Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
      BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A449.

    Entry informationi

    Entry nameiGPPA_AERS4
    AccessioniPrimary (citable) accession number: A4STJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3