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A4STJ8

- GPPA_AERS4

UniProt

A4STJ8 - GPPA_AERS4

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, ASA_4296
Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: InterPro
  3. phosphoric diester hydrolase activity Source: InterPro

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciASAL382245:GJJN-4282-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:ASA_4296
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000225: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_0000314492Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382245.ASA_4296.

Structurei

3D structure databases

ProteinModelPortaliA4STJ8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4STJ8-1 [UniParc]FASTAAdd to Basket

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MHNSPLYAAI DLGSNSFHML VVREVAGALR TVTKVKRKVR LAAGLDPEFR    50
LSRAAMERGW DCLRLFSEQL QDIPADNIRV VGTATLRLAT NVDEFLSEAE 100
RVLNHSIEII SGEEEAKTIY EGVSWTSAGE GNRLVIDIGG ASTELVIGEH 150
SEAKLLNSLH MGCVTWLNNH FGDGELSEAR FAQAIAAAKA VLEKVAEDYC 200
VLGWRTCVGA SGTVQALQEI MLAQGKSERV TLPKLQELMG QAIACGRLDR 250
LQLEGLAAER LTVFPSGLAI LIAIFETLNI ESMTLAGGAL REGLIYGLLG 300
NNHDCDARDR TADSLISCYQ LDKEHAERVR DTAIEAFNQL QPAWRLSKRY 350
GRPILRYAAL LHEIGLCIEY KKAPQHAAYI IDNIDMPGFT PAQKKLLSAL 400
LFNQRDEFKL ETLEKQGAVT GRQAIRLARI LRISLILCMR RTQGTVPNFT 450
LQAEEEALTL TLPKGWMDEH YLRASELRLE VERQQKMGWP TRLLEA 496
Length:496
Mass (Da):55,128
Last modified:May 15, 2007 - v1
Checksum:iDFAEF0947CFD692D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000644 Genomic DNA. Translation: ABO92220.1.
RefSeqiWP_005320675.1. NC_009348.1.
YP_001143968.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO92220; ABO92220; ASA_4296.
GeneIDi4997051.
KEGGiasa:ASA_4296.
PATRICi20795054. VBIAerSal2987_4261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000644 Genomic DNA. Translation: ABO92220.1 .
RefSeqi WP_005320675.1. NC_009348.1.
YP_001143968.1. NC_009348.1.

3D structure databases

ProteinModelPortali A4STJ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382245.ASA_4296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO92220 ; ABO92220 ; ASA_4296 .
GeneIDi 4997051.
KEGGi asa:ASA_4296.
PATRICi 20795054. VBIAerSal2987_4261.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci ASAL382245:GJJN-4282-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR006674. HD_domain.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
    Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
    BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A449.

Entry informationi

Entry nameiGPPA_AERS4
AccessioniPrimary (citable) accession number: A4STJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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