A4STE1 (G6PI_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	ASA_4235

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013938
Sites
	Active site	355	1	Proton donor By similarity
	Active site	386	1	By similarity
	Active site	514	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4STE1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 65F29B5ED77837F1	FASTA	549	61,202
	10 20 30 40 50 60 MKNINPTQTQ AWQALEAHFA ANKETRLKDL FAQDPKRFDK FSLTFGGDIL VDYSKNLITE 70 80 90 100 110 120 ETLKLLVDLA KETDLRSAID AMFNGEKINM TEGRSVLHVA LRNRSDRPIE CDGKDVMPEV 130 140 150 160 170 180 NAVLAKMKGF CEKIISGEWK GYTGKAIQHV VNIGIGGSDL GPVMITEALR PYKNHLQMHF 190 200 210 220 230 240 VSNVDGTHIA ETLKEIDAET TLFLVASKTF TTQETMTNAL TARDWFIKIA GDKAHVAKHF 250 260 270 280 290 300 AALSTNGKAV AEFGIDTDNM FEFWDWVGGR YSSWSAIGMP IALSVGFDNF EALLQGAFEM 310 320 330 340 350 360 DMHFATASYE QNVPVLLALI GLWYNNFHGA ESEAILPYDQ YMHRFPAYFQ QGNMESNGKY 370 380 390 400 410 420 VDRNGNPVDH QTGPIIWGEP GTNGQHAFYQ LIHQGTKLIP CDFLAPAISH NPIGDHHPKL 430 440 450 460 470 480 LANFFAQTEA LAFGKSKEQV EAEFLAAGKT LEQVEDLVPF KVFEGNRPTN SILFKSLTPK 490 500 510 520 530 540 TLGALIAMYE HKIFVQGAIW NIFSFDQWGV ELGKQLANKI LPELNTAEAV TSHDCSTNGL INTWKAWKA

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO92163.1.
RefSeq	YP_001143911.1. NC_009348.1.
3D structure databases
ProteinModelPortal	A4STE1.
SMR	A4STE1. Positions 10-542.
ModBase	Search...
Protein-protein interaction databases
STRING	A4STE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4996959.
GenomeReviews	Gene locus ASA_4235 in contig CP000644_GR.
KEGG	asa:ASA_4235.
PATRIC	20794930. VBIAerSal2987_4203.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	GPKIVSQ.
PhylomeDB	A4STE1.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_4235-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_AERS4

Accession

Primary (citable) accession number: A4STE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program