Reviewed, UniProtKB/Swiss-Prot A4STB6 (UBIC_AERS4)

Names and origin

Protein names

Recommended name:
    Probable chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	ASA_4209

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity.
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyruvate biosynthetic process Inferred from electronic annotation. Source: HAMAP ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000292060
Sites
	Binding site	37	1	Substrate; via amide nitrogen By similarity
	Binding site	78	1	Substrate By similarity
	Binding site	114	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4STB6-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: FABD2259CDE8473B	FASTA	178	20,160
	10 20 30 40 50 60 MKSELTVPLI QLAPWRVPAD CELPEALRPW LLEADSMTRR LRHHNRHFSV QLLGNRSVTL 70 80 90 100 110 120 CADEQQLVAA EQPMGLCREV ILHGDRGPAV LGWTLFAEAA LQESGLRELG EQPLGERIFG 130 140 150 160 170 DEPARRDHLQ LACFEIASNP WCPAATVWGR RSRLFLGQWP LLVHELFLPS LSCNKELE

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000644 Genomic DNA. Translation: ABO92138.1.
RefSeq	YP_001143886.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4STB6.
Genome annotation databases
GeneID	4996264.
GenomeReviews	Gene locus ASA_4209 in contig CP000644_GR.
KEGG	asa:ASA_4209.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LQITHTH.
Family and domain databases
HAMAP	MF_01632. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_AERS4

Accession

Primary (citable) accession number: A4STB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)