ID   A4SSF6_AERS4            Unreviewed;       843 AA.
AC   A4SSF6;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:ABO91828.1};
GN   OrderedLocusNames=ASA_3874 {ECO:0000313|EMBL:ABO91828.1};
OS   Aeromonas salmonicida (strain A449).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=382245 {ECO:0000313|EMBL:ABO91828.1, ECO:0000313|Proteomes:UP000000225};
RN   [1] {ECO:0000313|Proteomes:UP000000225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A449 {ECO:0000313|Proteomes:UP000000225};
RX   PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA   Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA   Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA   Brown L.L.;
RT   "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT   the evolution of a fish pathogen.";
RL   BMC Genomics 9:427-427(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; CP000644; ABO91828.1; -; Genomic_DNA.
DR   RefSeq; WP_005316190.1; NC_009348.1.
DR   AlphaFoldDB; A4SSF6; -.
DR   STRING; 29491.GCA_000820065_00881; -.
DR   KEGG; asa:ASA_3874; -.
DR   PATRIC; fig|382245.13.peg.3840; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   Proteomes; UP000000225; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          5..200
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   843 AA;  96965 MW;  44BE7720FBA5117B CRC64;
     MLVKLDTLVA RYDELNRLKT QRALGLMSRY GQQVFQLLPV MLHFNHPLLP GYVAGDVPHG
     IWSFTANEAQ QAFIQDLCQN ANCQNGLTTH DKSIQGLYSM GSTSSIGQCC HSDLDIWVCH
     VAGLSQARLE LLDLKCQQLS KWAEQRGVDL NFFLIPEDKF RQCNDAQMQG ESCGSAQHLL
     LLDEFYLSAM LIAGKRLLWY LVPAEYDDHY DEYVDSLFAD GKLSQDDWLD LGGFNRIPAE
     EYFGSALWQL YKGIDSPYKA VLKSVLMEAY SHEYPNTRLL SVTSRDWFQH NDGMHYRLDN
     YCLMLDKVTN YLKSIGDMQR LDLVRRCFYL KVCDGLSHPK EEHSPAWRRE QMTQLVSYWG
     WSPERLHHLD HRQEWKVEDV KVAHAELLEA LMQSYRNLIQ FARRNNISES INPEDIGILS
     RKLYAAFESL PGKVQRINLT IAPDLSEQDL SLVQVPHGRL NRAGWYLYKH SLDPVDIIGR
     APLEYNGYIS KLVSWAYFNG LLTPQSRVHL FNQGSDLHID NLHQFCRDLS GTFPVKYPRA
     TNLALSRPCE IRQLSIFLNL ETDPTSHWMG QVIEFDANAA DVFSFGRNQE CLVGSVDLVY
     RNSWSEIRTL HFQGDEAVVD ALTTILGKMH QDAAAPEMIE VFCYSQHFRS LIRTRFQQLV
     AECIELRLAR DKLQLVKTLA LGREKYGIFF ERRGVSVKKL ENAIDFYRHI SHNKLDHLPL
     RLDKTHSQHL PDIVDAYASE GLVQFFFDTR DAGTNIYILD EANRVEIYQH FAGNKNELVQ
     GVNRFYASSH ERFSDAGQFS NFNLPQYYEI VQINGELEVI PYRSQGQMRD NASPAHELGS
     ATG
//