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Protein

Adenylate cyclase

Gene

cyaA

Organism
Aeromonas salmonicida (strain A449)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.UniRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

cAMP biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciASAL382245:GJJN-3861-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclaseUniRule annotation (EC:4.6.1.1UniRule annotation)
Gene namesi
Name:cyaAImported
Ordered Locus Names:ASA_3874Imported
OrganismiAeromonas salmonicida (strain A449)Imported
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000225: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi382245.ASA_3874.

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiPIHGLFL.
OrthoDBiEOG63JR9H.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SSF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVKLDTLVA RYDELNRLKT QRALGLMSRY GQQVFQLLPV MLHFNHPLLP
60 70 80 90 100
GYVAGDVPHG IWSFTANEAQ QAFIQDLCQN ANCQNGLTTH DKSIQGLYSM
110 120 130 140 150
GSTSSIGQCC HSDLDIWVCH VAGLSQARLE LLDLKCQQLS KWAEQRGVDL
160 170 180 190 200
NFFLIPEDKF RQCNDAQMQG ESCGSAQHLL LLDEFYLSAM LIAGKRLLWY
210 220 230 240 250
LVPAEYDDHY DEYVDSLFAD GKLSQDDWLD LGGFNRIPAE EYFGSALWQL
260 270 280 290 300
YKGIDSPYKA VLKSVLMEAY SHEYPNTRLL SVTSRDWFQH NDGMHYRLDN
310 320 330 340 350
YCLMLDKVTN YLKSIGDMQR LDLVRRCFYL KVCDGLSHPK EEHSPAWRRE
360 370 380 390 400
QMTQLVSYWG WSPERLHHLD HRQEWKVEDV KVAHAELLEA LMQSYRNLIQ
410 420 430 440 450
FARRNNISES INPEDIGILS RKLYAAFESL PGKVQRINLT IAPDLSEQDL
460 470 480 490 500
SLVQVPHGRL NRAGWYLYKH SLDPVDIIGR APLEYNGYIS KLVSWAYFNG
510 520 530 540 550
LLTPQSRVHL FNQGSDLHID NLHQFCRDLS GTFPVKYPRA TNLALSRPCE
560 570 580 590 600
IRQLSIFLNL ETDPTSHWMG QVIEFDANAA DVFSFGRNQE CLVGSVDLVY
610 620 630 640 650
RNSWSEIRTL HFQGDEAVVD ALTTILGKMH QDAAAPEMIE VFCYSQHFRS
660 670 680 690 700
LIRTRFQQLV AECIELRLAR DKLQLVKTLA LGREKYGIFF ERRGVSVKKL
710 720 730 740 750
ENAIDFYRHI SHNKLDHLPL RLDKTHSQHL PDIVDAYASE GLVQFFFDTR
760 770 780 790 800
DAGTNIYILD EANRVEIYQH FAGNKNELVQ GVNRFYASSH ERFSDAGQFS
810 820 830 840
NFNLPQYYEI VQINGELEVI PYRSQGQMRD NASPAHELGS ATG
Length:843
Mass (Da):96,965
Last modified:May 15, 2007 - v1
Checksum:i44BE7720FBA5117B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO91828.1.
RefSeqiWP_005316190.1. NC_009348.1.
YP_001143576.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO91828; ABO91828; ASA_3874.
GeneIDi4998010.
KEGGiasa:ASA_3874.
PATRICi20794180. VBIAerSal2987_3840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO91828.1.
RefSeqiWP_005316190.1. NC_009348.1.
YP_001143576.1. NC_009348.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi382245.ASA_3874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO91828; ABO91828; ASA_3874.
GeneIDi4998010.
KEGGiasa:ASA_3874.
PATRICi20794180. VBIAerSal2987_3840.

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiPIHGLFL.
OrthoDBiEOG63JR9H.

Enzyme and pathway databases

BioCyciASAL382245:GJJN-3861-MONOMER.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
    Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
    BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A449Imported.

Entry informationi

Entry nameiA4SSF6_AERS4
AccessioniPrimary (citable) accession number: A4SSF6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.