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A4SS45 (MTLD_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:ASA_3756
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011791

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A4SS45 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: D72A40F1945E7C8B

FASTA38141,454
        10         20         30         40         50         60 
MKTLHFGAGN IGRGFIGKLL ADASHQVTFA DVNETLIDQL NHRQEYKVHV VGADQKLDVV 

        70         80         90        100        110        120 
RNVAAVSSAG HEVIARIITA DLVTTAVGPN ILDKIASTLA KGLQARFDAG NLSPLNVIAC 

       130        140        150        160        170        180 
ENMVRGTSHL KQEVLKYLPV AYHATHESCV GFVDSAVDRI VPPAAANDDP LEVTVESFSE 

       190        200        210        220        230        240 
WIVDQTQFKG ELPQVAGMEP TDNLMAFVER KLFTLNTGHI VTAYLGKLRG YRTIREAIED 

       250        260        270        280        290        300 
PVIRSKVRRA MEESGAVLVK RYGFDPRLHA AYIEKILARF ANPYLVDEID RVGRQPLRKL 

       310        320        330        340        350        360 
AAGDRLVKPL LGTLEYGLPS DHLQEGIAAA LHYCNADDPQ AVELQALLAE LGPAQALARV 

       370        380 
TGLAADSDIV SAIVARYDSL K

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References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000644 Genomic DNA. Translation: ABO91717.1.
RefSeqYP_001143465.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SS45.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4SS45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4994872.
GenomeReviewsGene locus ASA_3756 in contig CP000644_GR.
KEGGasa:ASA_3756.
PATRIC20793948. VBIAerSal2987_3729.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHBG568825.
OMAFANTAVD.
PhylomeDBA4SS45.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycASAL382245:ASA_3756-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_AERS4
AccessionPrimary (citable) accession number: A4SS45
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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