Reviewed, UniProtKB/Swiss-Prot A4SS45 (MTLD_AERS4)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	ASA_3756

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000011791
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4SS45-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: D72A40F1945E7C8B	FASTA	381	41,454
	10 20 30 40 50 60 MKTLHFGAGN IGRGFIGKLL ADASHQVTFA DVNETLIDQL NHRQEYKVHV VGADQKLDVV 70 80 90 100 110 120 RNVAAVSSAG HEVIARIITA DLVTTAVGPN ILDKIASTLA KGLQARFDAG NLSPLNVIAC 130 140 150 160 170 180 ENMVRGTSHL KQEVLKYLPV AYHATHESCV GFVDSAVDRI VPPAAANDDP LEVTVESFSE 190 200 210 220 230 240 WIVDQTQFKG ELPQVAGMEP TDNLMAFVER KLFTLNTGHI VTAYLGKLRG YRTIREAIED 250 260 270 280 290 300 PVIRSKVRRA MEESGAVLVK RYGFDPRLHA AYIEKILARF ANPYLVDEID RVGRQPLRKL 310 320 330 340 350 360 AAGDRLVKPL LGTLEYGLPS DHLQEGIAAA LHYCNADDPQ AVELQALLAE LGPAQALARV 370 380 TGLAADSDIV SAIVARYDSL K

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000644 Genomic DNA. Translation: ABO91717.1.
RefSeq	YP_001143465.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4994872.
GenomeReviews	Gene locus ASA_3756 in contig CP000644_GR.
KEGG	asa:ASA_3756.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_AERS4

Accession

Primary (citable) accession number: A4SS45

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	November 25, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)