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Protein

Catalase-peroxidase

Gene

katG

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69Transition state stabilizerUniRule annotation1
Active sitei73Proton acceptorUniRule annotation1
Metal bindingi241Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:ASA_3715
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000225 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547141 – 699Catalase-peroxidaseAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki72 ↔ 200Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-226)UniRule annotation
Cross-linki200 ↔ 226Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-72)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA4SS04.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi382245.ASA_3715.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SS04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNSERSQG KCPVMHGGTT SGEQANMAWW PKSLNLDMAA LKQDVTALMT
60 70 80 90 100
DSQDWWPADW GHYGALMIRM AWHSAGTYRI ADGRGGGSTG NQRFAPLNSW
110 120 130 140 150
PDNANLDKAR RLLWPIKKKY GNKISWADLI ILAGTVAYES MGLKTFGFAF
160 170 180 190 200
GREDIWHPEK DIYWGAEKEW LAPSSKPGGR YSGERDLDNP LAAVMMGLIY
210 220 230 240 250
VNPEGVDGNP DPLKTAKDMR VTFARMAMDD EETVALTAGG HTVGKCHGNG
260 270 280 290 300
DARLLGPEPE GAAVEDQGLG WLNKTQRGIG RNAVTSGIEG AWTTHPTRWD
310 320 330 340 350
NGYFYLLFNY EWELKKSPAG AWQWEPVNIR EEDKPVDVED PAIRHNPIMT
360 370 380 390 400
DADMALKFDP EYRKIAERFR ADPAAFSDAF ARAWFKLTHR DLGPKTRYVG
410 420 430 440 450
PYVPAEDLIW QDPVPAGRTD YDVAAVKASI AASGLSISDM VSTAWDSART
460 470 480 490 500
FRGSDLRGGA NGARIRLAPQ NEWEGNEPAR LARVLKVLEP IAAASQISVA
510 520 530 540 550
DVIVLAGNLG VELAARAAGV EVTVPFSPGR GDASQARTDV ASFDVLEPLA
560 570 580 590 600
DGYRNWLKKD YAVTAEELML DRTQLMGLTA HEMTVLVGGM RVLGTNHGGT
610 620 630 640 650
RHGVFTEREG ALTNDYFVNL TDMANTWHPS GDRLYEVRDR KSGKVKWTAT
660 670 680 690
RIDLVFGSNS VLRAYAEVYA QDDNKEKFVC DFISAWNKVM NADRFDLMS
Length:699
Mass (Da):77,263
Last modified:May 15, 2007 - v1
Checksum:i5B05B9F09887CBAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO91676.1.
RefSeqiWP_005316054.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO91676; ABO91676; ASA_3715.
GeneIDi4997584.
KEGGiasa:ASA_3715.
PATRICi20793870. VBIAerSal2987_3690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO91676.1.
RefSeqiWP_005316054.1. NC_009348.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi382245.ASA_3715.

Proteomic databases

PRIDEiA4SS04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO91676; ABO91676; ASA_3715.
GeneIDi4997584.
KEGGiasa:ASA_3715.
PATRICi20793870. VBIAerSal2987_3690.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_AERS4
AccessioniPrimary (citable) accession number: A4SS04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.