A4SRU4 (DEOC_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	ASA_3655

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00592
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_1000072593
Sites
	Active site	166	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	198	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4SRU4 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: DACFDB22583EB599	FASTA	257	27,404
	10 20 30 40 50 60 MTDLKLAAQR ALNLMDLTTL NDDDTDQKVV DLCRKAKSPA GLTAAVCIYP RFIPIARKTL 70 80 90 100 110 120 REIGAADVRI ATVTNFPHGN DDIEIAVAET RAAVAYGADE VDVVFPYRAF MAGNEQVGFD 130 140 150 160 170 180 LVKACKEACG DKALLKVIIE TGELKEEALI RRASEICIDA GADFIKTSTG KVPVNATPEA 190 200 210 220 230 240 ARIMMEVIKA KNPKVGFKPA GGVKDAAVAG QYLAMAEEIL GKEWVSARTF RFGASSLLAS 250 LLATLGHGDK PANTSGY

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO91616.1.
RefSeq	YP_001143364.1. NC_009348.1.
3D structure databases
ProteinModelPortal	A4SRU4.
SMR	A4SRU4. Positions 1-248.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SRU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4994648.
GenomeReviews	Gene locus ASA_3655 in contig CP000644_GR.
KEGG	asa:ASA_3655.
PATRIC	20793750. VBIAerSal2987_3630.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HBG636421.
OMA	FELVKQC.
PhylomeDB	A4SRU4.
ProtClustDB	PRK05283.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_3655-MONOMER.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR023649. DeoC_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_AERS4

Accession

Primary (citable) accession number: A4SRU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program