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A4SRU3 (TYPH_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:ASA_3654
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000069655

Sequences

Sequence LengthMass (Da)Tools
A4SRU3 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 5E92E37014707542

FASTA44346,920
        10         20         30         40         50         60 
MFLPQEIIRK KRNGEALSTQ EIQFFVQGIT NNTIGEGQIA ALAMAVYFKD MTMDERVALT 

        70         80         90        100        110        120 
CAMRDSGMVL NWEHLNLGGP IVDKHSTGGV GDVVSLMLGP MVAACGGFVP MISGRGLGHT 

       130        140        150        160        170        180 
GGTLDKLDAI PGYQTSVDND RFLKVVKEAG VAIIGQTGDL APADKRIYAV RDITATVESI 

       190        200        210        220        230        240 
AMITGSILSK KLASGLEALV MDVKVGSGAF MPTFEASEEL AKSIVAVANG AGCRTSALLT 

       250        260        270        280        290        300 
DMNQVLASSA GNGVEVREAV RYLTGEYRNP RIHEVTMSLC AEMLISAHLA SDDADARRKL 

       310        320        330        340        350        360 
QAVLDNGKAA EIFGRMVTGL GGPSDFMERY DSYLPKAAIV RPVYAANAGF VTAMDTRELG 

       370        380        390        400        410        420 
LAVVAMGGGR RAAGDKLDYA VGLTDFIRLG QSVDADKPLA LIHAQTEDQF AQAASMVQAA 

       430        440 
VKIGDTQPQA LPEVYRRIGL ADL 

« Hide

References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000644 Genomic DNA. Translation: ABO91615.1.
RefSeqYP_001143363.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SRU3.
SMRA4SRU3. Positions 1-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382245.ASA_3654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO91615; ABO91615; ASA_3654.
GeneID4994647.
KEGGasa:ASA_3654.
PATRIC20793748. VBIAerSal2987_3629.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMADVWRRMI.
OrthoDBEOG61ZTGG.
ProtClustDBCLSK728803.

Enzyme and pathway databases

BioCycASAL382245:GJJN-3641-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_AERS4
AccessionPrimary (citable) accession number: A4SRU3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways