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Protein

60 kDa chaperonin

Gene

groL

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60
Gene namesi
Name:groL
Synonyms:groEL
Ordered Locus Names:ASA_3431
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000225 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000257491 – 54460 kDa chaperoninAdd BLAST544

Proteomic databases

PRIDEiA4SR80.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.

Protein-protein interaction databases

STRINGi382245.ASA_3431.

Structurei

3D structure databases

ProteinModelPortaliA4SR80.
SMRiA4SR80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

A4SR80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKEVKFGN EARIKMLEGV NILADAVKVT LGPKGRNVVL DKSFGAPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFQNMG AQMVKEVASK ANDAAGDGTT TATVLAQAIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKAVIAAVAE LQVLSQPCAD NNAIAQVGTI
160 170 180 190 200
SANSDEKVGR LIAEAMDKVG RDGVITVEDG QGLDDELAVV EGMQFDRGYL
210 220 230 240 250
SPYFVNKPET GAVELDDPFI LLVDKKVSNI REMLPVLEGV AKAGKPLLIV
260 270 280 290 300
AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIAMLTGGTV
310 320 330 340 350
ISEEVGMELE KATLEDLGRA KRIVITKENT TIIDGVGDAA LIESRVAQIR
360 370 380 390 400
QQIEETSSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVDDAL
410 420 430 440 450
HATRAAVEEG VVAGGGVALV RVAAKLAGLR GDNEDQNVGI KVALRAMEAP
460 470 480 490 500
LRQIVINAGE EASVIANAVK NGEGNFGYNA YTEQYGDMLA MGILDPTKVT
510 520 530 540
RSALQFASSI AGLMITTECM ITELPKKDTP AMPDMGGMGG MGMM
Length:544
Mass (Da):57,320
Last modified:May 15, 2007 - v1
Checksum:iC40F7C207B61F690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO91402.1.
RefSeqiWP_005318975.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO91402; ABO91402; ASA_3431.
GeneIDi4995399.
KEGGiasa:ASA_3431.

Similar proteinsi

Entry informationi

Entry nameiCH60_AERS4
AccessioniPrimary (citable) accession number: A4SR80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families