Reviewed, UniProtKB/Swiss-Prot A4SR47 (PUR7_AERS4)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	ASA_3394

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000117821

Sequences

	Sequence		Length	Mass (Da)
	A4SR47-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: F1B3CF5651339453	FASTA	367	41,035
	10 20 30 40 50 60 MSLADQVLAV NDDLPIRTDK PVHSGKVRSV YWLTPEDSAR LIKEKGYDVP ADAPLALMVI 70 80 90 100 110 120 SDRISAFDCI WQGVDGLNGV PGKGAALNAI SSHWFKLFKE KGLADSHILD IPHPFVWIVQ 130 140 150 160 170 180 KARPVMIEAI ARQYITGSMW RAYKDGEREF CGITLPEGLK KDQKLPEILI TPSTKGVLTG 190 200 210 220 230 240 LDGVPEADDV NVSRADIERH YQGFNFSKPA DIDRYEVLLK EGFNVISDAL ASLDQIFVDT 250 260 270 280 290 300 KFEFGYVQDA AGNEKLIYMD EVGTPDSSRI WDGAALRDGQ IVEKSKEGFR QWLLNHFPDP 310 320 330 340 350 360 DILLNKNRMP ERFALAKGNK LPTEVMMDIS NTYVGIAEKI IGHPLVRSAN PKQEIIEVLR DQYGLID

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000644 Genomic DNA. Translation: ABO91369.1.
RefSeq	YP_001143117.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4SR47.
Genome annotation databases
GeneID	4998519.
GenomeReviews	Gene locus ASA_3394 in contig CP000644_GR.
KEGG	asa:ASA_3394.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SSRIWDG.
Family and domain databases
HAMAP	MF_00137. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 2 hits. [Graphical view]
ProDom	PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02735. purC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. False negative. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_AERS4

Accession

Primary (citable) accession number: A4SR47

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)