Reviewed, UniProtKB/Swiss-Prot A4SQ27 (PPNK_AERS4)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase
      Short name=Poly(P)/ATP NAD kinase
    EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	ASA_2998

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000079478

Sequences

	Sequence		Length	Mass (Da)
	A4SQ27-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 4908E4355FCC7DB7	FASTA	294	32,155
	10 20 30 40 50 60 MDSPFKTIAL IGKPHHEGAN QTLTGLHQYL TTRGFKVLVE SRVAHTLGIM DENVMDLVQL 70 80 90 100 110 120 GEQADLAIVV GGDGNMLGAA RVLSRFDVAV IGVNRGNLGF LTDLSPQDYL LPLEQVLSGH 130 140 150 160 170 180 YKSEHRFLLE AAVYRHGERK SSNLAVNEAV LHPGKIAHMI EFEVYIDGSF MYSQRSDGII 190 200 210 220 230 240 VATPTGSTAY SLSAGGAILT PKLNAITLVP MFPHTLSSRP IVLDADSEVR LLVSPDNQDD 250 260 270 280 290 AMQVSCDGQV TLAVHPGDEI LIKKSKHKLH LVHPLDYSYF HVLRNKLGWG SKLF

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000644 Genomic DNA. Translation: ABO90999.1.
RefSeq	YP_001142747.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4SQ27.
Genome annotation databases
GeneID	4995764.
GenomeReviews	Gene locus ASA_2998 in contig CP000644_GR.
KEGG	asa:ASA_2998.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MEQFRNI.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR002504. ATP_NADK. [Graphical view]
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK_AERS4

Accession

Primary (citable) accession number: A4SQ27

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)