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A4SPE5

- FTHS_AERS4

UniProt

A4SPE5 - FTHS_AERS4

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, ASA_2749
Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASAL382245:GJJN-2738-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:ASA_2749
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000225: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000300515Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382245.ASA_2749.

Structurei

3D structure databases

ProteinModelPortaliA4SPE5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SPE5-1 [UniParc]FASTAAdd to Basket

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MLSDIEISRQ SPRLSIQALA SRLGIPAHLL SPHGHYKGKL SLELLKQAAS    50
KPGKKAGKLV LVSAITPTPL GEGKTVTTLG LSMGLNHIGQ PSMATIRQPS 100
LGPVFGVKGG AAGGGHAQVV PMEEMNLHLT GDFHALTAAH NLAAAALDAR 150
LFHETKLGTE FTARTGLARL DIDPANILWP RTLDMNERAL RHLTIGQGAA 200
ADGVERQDRF VITAASELMA ILALASDLKD LRARIGRIQL ALDSQGQPIT 250
AEQLEVAGAM TVLLKDALQP TLMQTTEQTP VLVHAGPFAN IAHGNSSVIA 300
DRMALQLTDY VVTEAGFGSD MGLEKFFNIK HRQSGITPAC VVLVATVRGL 350
KANSGLLDIR PGQPLPASLL GEDLPTLEKG CANLAWHIHN ARRYGLPVVV 400
AVNSFPTDSK AELDLLMREA RQAGACGAAI STAFVEGGAG ASELARAVVA 450
ACEMPSQIQL LYPDEMSLCA KLATLVECGY GGRGVILSDK AHRQLAALSA 500
AGWDHLPICV AKTPLSISHD PARKGVPTDF EVPIDEVKLC AGAGFVYALA 550
GPIMTMPGLG SLPAYRHIDI GEDGEIVGLS 580
Length:580
Mass (Da):60,953
Last modified:May 15, 2007 - v1
Checksum:i3E6AFCE1DCF8BBA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000644 Genomic DNA. Translation: ABO90767.1.
RefSeqiYP_001142515.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO90767; ABO90767; ASA_2749.
GeneIDi4995845.
KEGGiasa:ASA_2749.
PATRICi20791897. VBIAerSal2987_2724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000644 Genomic DNA. Translation: ABO90767.1 .
RefSeqi YP_001142515.1. NC_009348.1.

3D structure databases

ProteinModelPortali A4SPE5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 382245.ASA_2749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO90767 ; ABO90767 ; ASA_2749 .
GeneIDi 4995845.
KEGGi asa:ASA_2749.
PATRICi 20791897. VBIAerSal2987_2724.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ASAL382245:GJJN-2738-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
    Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
    BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A449.

Entry informationi

Entry nameiFTHS_AERS4
AccessioniPrimary (citable) accession number: A4SPE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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