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A4SPE5 (FTHS_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:ASA_2749
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300515

Regions

Nucleotide binding68 – 758ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A4SPE5 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 3E6AFCE1DCF8BBA2

FASTA58060,953
        10         20         30         40         50         60 
MLSDIEISRQ SPRLSIQALA SRLGIPAHLL SPHGHYKGKL SLELLKQAAS KPGKKAGKLV 

        70         80         90        100        110        120 
LVSAITPTPL GEGKTVTTLG LSMGLNHIGQ PSMATIRQPS LGPVFGVKGG AAGGGHAQVV 

       130        140        150        160        170        180 
PMEEMNLHLT GDFHALTAAH NLAAAALDAR LFHETKLGTE FTARTGLARL DIDPANILWP 

       190        200        210        220        230        240 
RTLDMNERAL RHLTIGQGAA ADGVERQDRF VITAASELMA ILALASDLKD LRARIGRIQL 

       250        260        270        280        290        300 
ALDSQGQPIT AEQLEVAGAM TVLLKDALQP TLMQTTEQTP VLVHAGPFAN IAHGNSSVIA 

       310        320        330        340        350        360 
DRMALQLTDY VVTEAGFGSD MGLEKFFNIK HRQSGITPAC VVLVATVRGL KANSGLLDIR 

       370        380        390        400        410        420 
PGQPLPASLL GEDLPTLEKG CANLAWHIHN ARRYGLPVVV AVNSFPTDSK AELDLLMREA 

       430        440        450        460        470        480 
RQAGACGAAI STAFVEGGAG ASELARAVVA ACEMPSQIQL LYPDEMSLCA KLATLVECGY 

       490        500        510        520        530        540 
GGRGVILSDK AHRQLAALSA AGWDHLPICV AKTPLSISHD PARKGVPTDF EVPIDEVKLC 

       550        560        570        580 
AGAGFVYALA GPIMTMPGLG SLPAYRHIDI GEDGEIVGLS 

« Hide

References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000644 Genomic DNA. Translation: ABO90767.1.
RefSeqYP_001142515.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SPE5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382245.ASA_2749.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO90767; ABO90767; ASA_2749.
GeneID4995845.
KEGGasa:ASA_2749.
PATRIC20791897. VBIAerSal2987_2724.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycASAL382245:GJJN-2738-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_AERS4
AccessionPrimary (citable) accession number: A4SPE5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways