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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:ASA_2740
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000225 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000242521 – 633Biosynthetic arginine decarboxylaseAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi382245.ASA_2740

Structurei

3D structure databases

ProteinModelPortaliA4SPD6
SMRiA4SPD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni284 – 294Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4SPD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNWSSKDSL KVYNVPYWGA GFFNINDAGH VTVAPDKSRP DAHIVISDAI
60 70 80 90 100
EQLRQSGLTT PVLLRFPDIL KSRVDALFNA FGQAIEKSGY EGDYLCVYPI
110 120 130 140 150
KVNQQSRVIE TISQSYSDKP RLGLEAGSKP ELLAVLSHHH EQGSVIVCNG
160 170 180 190 200
YKDREYIRHA LLGNLMGHKV YIVVEKPSEL EMVLDESARL NIKPNIGVRA
210 220 230 240 250
KLASTGSGMW ESSGGSMSKF GLSASQILAL VERLRSLDKL DCLQLLHFHL
260 270 280 290 300
GSQIANIRDI QGGIRECGRF YSELRRLGVP IDVVDVGGGL GVDYEGTRSQ
310 320 330 340 350
SHCSANYSLS EYANNVVWGI GDVCREFDLP YPTIISESGR ALTAHHAVLV
360 370 380 390 400
TNLIGAEGVE MSDISAPDED APTLLQNMWQ GWLDLRGEDP SLLEIFHDSV
410 420 430 440 450
ADLGDVNTQY TMGLLNLEQR AWAEMLHQNT CLALKEMLNP VNRNHRALAD
460 470 480 490 500
ELSEKLADKC FANFSLFQSL PDAWGIGQVF PVMPLTGLDR PLSRRGILMD
510 520 530 540 550
ITCDSDGQVE HYVDGLGVES TLPMPQYEEN EVCYVGFFLV GAYQEILGDL
560 570 580 590 600
HNLFGDTHCA EVCLDEEGKM DIRNVVRGDT VDQLLRYVNI DPSVIRENYQ
610 620 630
RIVSHPALDD ATRKALLDEL ELGLQGYAYL EDE
Length:633
Mass (Da):70,262
Last modified:May 15, 2007 - v1
Checksum:i75DA089696A72486
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA Translation: ABO90758.1
RefSeqiWP_005309971.1, NC_009348.1

Genome annotation databases

EnsemblBacteriaiABO90758; ABO90758; ASA_2740
GeneIDi4995209
KEGGiasa:ASA_2740
PATRICifig|382245.13.peg.2714

Similar proteinsi

Entry informationi

Entry nameiSPEA_AERS4
AccessioniPrimary (citable) accession number: A4SPD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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