Reviewed, UniProtKB/Swiss-Prot A4SPD6 (SPEA_AERS4)

Names and origin

Protein names

Recommended name:
    Biosynthetic arginine decarboxylase
      Short name=ADC
    EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	ASA_2740

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	633 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 633	633	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_1000024252
Regions
	Region	284 – 294	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	101	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4SPD6-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 75DA089696A72486	FASTA	633	70,262
	10 20 30 40 50 60 MTNWSSKDSL KVYNVPYWGA GFFNINDAGH VTVAPDKSRP DAHIVISDAI EQLRQSGLTT 70 80 90 100 110 120 PVLLRFPDIL KSRVDALFNA FGQAIEKSGY EGDYLCVYPI KVNQQSRVIE TISQSYSDKP 130 140 150 160 170 180 RLGLEAGSKP ELLAVLSHHH EQGSVIVCNG YKDREYIRHA LLGNLMGHKV YIVVEKPSEL 190 200 210 220 230 240 EMVLDESARL NIKPNIGVRA KLASTGSGMW ESSGGSMSKF GLSASQILAL VERLRSLDKL 250 260 270 280 290 300 DCLQLLHFHL GSQIANIRDI QGGIRECGRF YSELRRLGVP IDVVDVGGGL GVDYEGTRSQ 310 320 330 340 350 360 SHCSANYSLS EYANNVVWGI GDVCREFDLP YPTIISESGR ALTAHHAVLV TNLIGAEGVE 370 380 390 400 410 420 MSDISAPDED APTLLQNMWQ GWLDLRGEDP SLLEIFHDSV ADLGDVNTQY TMGLLNLEQR 430 440 450 460 470 480 AWAEMLHQNT CLALKEMLNP VNRNHRALAD ELSEKLADKC FANFSLFQSL PDAWGIGQVF 490 500 510 520 530 540 PVMPLTGLDR PLSRRGILMD ITCDSDGQVE HYVDGLGVES TLPMPQYEEN EVCYVGFFLV 550 560 570 580 590 600 GAYQEILGDL HNLFGDTHCA EVCLDEEGKM DIRNVVRGDT VDQLLRYVNI DPSVIRENYQ 610 620 630 RIVSHPALDD ATRKALLDEL ELGLQGYAYL EDE

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000644 Genomic DNA. Translation: ABO90758.1.
RefSeq	YP_001142506.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4SPD6.
Genome annotation databases
GeneID	4995209.
GenomeReviews	Gene locus ASA_2740 in contig CP000644_GR.
KEGG	asa:ASA_2740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LICNGYK.
Family and domain databases
HAMAP	MF_01417. [Tree]
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. False negative. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_AERS4

Accession

Primary (citable) accession number: A4SPD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)