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A4SPD6 (SPEA_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:ASA_2740
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000024252

Regions

Region284 – 29411Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4SPD6 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 75DA089696A72486

FASTA63370,262
        10         20         30         40         50         60 
MTNWSSKDSL KVYNVPYWGA GFFNINDAGH VTVAPDKSRP DAHIVISDAI EQLRQSGLTT 

        70         80         90        100        110        120 
PVLLRFPDIL KSRVDALFNA FGQAIEKSGY EGDYLCVYPI KVNQQSRVIE TISQSYSDKP 

       130        140        150        160        170        180 
RLGLEAGSKP ELLAVLSHHH EQGSVIVCNG YKDREYIRHA LLGNLMGHKV YIVVEKPSEL 

       190        200        210        220        230        240 
EMVLDESARL NIKPNIGVRA KLASTGSGMW ESSGGSMSKF GLSASQILAL VERLRSLDKL 

       250        260        270        280        290        300 
DCLQLLHFHL GSQIANIRDI QGGIRECGRF YSELRRLGVP IDVVDVGGGL GVDYEGTRSQ 

       310        320        330        340        350        360 
SHCSANYSLS EYANNVVWGI GDVCREFDLP YPTIISESGR ALTAHHAVLV TNLIGAEGVE 

       370        380        390        400        410        420 
MSDISAPDED APTLLQNMWQ GWLDLRGEDP SLLEIFHDSV ADLGDVNTQY TMGLLNLEQR 

       430        440        450        460        470        480 
AWAEMLHQNT CLALKEMLNP VNRNHRALAD ELSEKLADKC FANFSLFQSL PDAWGIGQVF 

       490        500        510        520        530        540 
PVMPLTGLDR PLSRRGILMD ITCDSDGQVE HYVDGLGVES TLPMPQYEEN EVCYVGFFLV 

       550        560        570        580        590        600 
GAYQEILGDL HNLFGDTHCA EVCLDEEGKM DIRNVVRGDT VDQLLRYVNI DPSVIRENYQ 

       610        620        630 
RIVSHPALDD ATRKALLDEL ELGLQGYAYL EDE 

« Hide

References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000644 Genomic DNA. Translation: ABO90758.1.
RefSeqYP_001142506.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SPD6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382245.ASA_2740.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO90758; ABO90758; ASA_2740.
GeneID4995209.
KEGGasa:ASA_2740.
PATRIC20791877. VBIAerSal2987_2714.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycASAL382245:GJJN-2729-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_AERS4
AccessionPrimary (citable) accession number: A4SPD6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways