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Reviewed, UniProtKB/Swiss-Prot A4SPA7 (GLPK_AERS4)

Last modified November 3, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: ASA_2710
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

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Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Glycerol kinase HAMAP MF_00186
PRO_1000020694

Regions

Nucleotide binding411 – 4155ATP By similarity

Sites

Binding site151Substrate By similarity
Binding site191ATP By similarity
Binding site851Substrate By similarity
Binding site1371Substrate By similarity
Binding site2451Substrate By similarity
Binding site2671ATP By similarity
Binding site3101ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
A4SPA7-1 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: B08C8EBCDF230D3B

FASTA50055,493
        10         20         30         40         50         60 
MSAEKKYVVA LDQGTTSSRA IVFDQDANIV GTSQREFTQH YPKAGWVEHD PMEIWATQSS 

        70         80         90        100        110        120 
VFTEVLAKTG LRSEEIAAIG ITNQRETTVV WEKATGKPIY NAIVWQCRRT AAICEELKAR 

       130        140        150        160        170        180 
GLEEYVRENT GLVLDAYFSG TKVKWILDNV EGAREKAMNG ELLFGTIDTW LVWKMTNGEV 

       190        200        210        220        230        240 
HVTDPTNASR TMLYNIRDLK WDEKMLDELG IPLSMLPEVK PSSEVYGYTT RGGGSRIPIA 

       250        260        270        280        290        300 
GIAGDQQSAL FGQLCFEKGM AKNTYGTGCF LLMNTGTEPV RSSNGLLTTV AIGPKGEVNY 

       310        320        330        340        350        360 
ALEGAVFMGG ATVQWLRDEL KLIHDARDTD YFASKVGDTN GVYLVPAFVG LGAPYWDPYA 

       370        380        390        400        410        420 
RGTMVGLTRG ANRNHIIRAA LESIAYQSRD VLDAMQQDSG IKLAALKVDG GAVANDFLMQ 

       430        440        450        460        470        480 
FQSDMMHTPV VRPTRIETTA MGAAFLAGLA VGFWKSSDEL EDKFSVDREF IPQMSHEERN 

       490        500 
KLYHGWQKAV ERSRRWAEED

« Hide

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References

[1]"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449."
Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000644 Genomic DNA. Translation: ABO90729.1.
RefSeqYP_001142477.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4SPA7.

Genome annotation databases

GeneID4995170.
GenomeReviewsGene locus ASA_2710 in contig CP000644_GR.
KEGGasa:ASA_2710.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIAQREFT.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_AERS4
AccessionPrimary (citable) accession number: A4SPA7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents