A4SP35 (GCST_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	ASA_2633

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_1000047642

Sequences

	Sequence		Length	Mass (Da)
	A4SP35 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 268D58EE879D6243	FASTA	365	39,692
	10 20 30 40 50 60 MIQTTVLHPK HLEAGAKMVD FHGWEMPINY GSQLEEHHAV RTDAGMFDVS HMTIVDLTGE 70 80 90 100 110 120 RVKAFLQHLL ANDVAKLTVP GKALYSGMLN PDGGVIDDLI TYYLTDTFYR LVVNSATREK 130 140 150 160 170 180 DLAWIRHHAI DFAVSVTERP ELAMIAVQGP NAKAKAAKVF TPEQNAAVEG MKPFFGVQAG 190 200 210 220 230 240 DLFIATTGYT GEDGYEIVVP QEKACDLWQA LLDNGVAPCG LGARDTLRLE AGMNLYSQDM 250 260 270 280 290 300 DESISPLAAN MAWTLAFEPA SRQFIGRAAL EAQKAAGTQL KQVGLVMEEK GVLRAGMPVT 310 320 330 340 350 360 FTTASGEKRE GVITSGSFSP TLGYSIALAR VPRDIGEQAE VEIRKKLVTV KVTKPAFVRN GQKLV

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO90657.1.
RefSeq	YP_001142405.1. NC_009348.1.
3D structure databases
ProteinModelPortal	A4SP35.
SMR	A4SP35. Positions 5-364.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SP35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4995253.
GenomeReviews	Gene locus ASA_2633 in contig CP000644_GR.
KEGG	asa:ASA_2633.
PATRIC	20791648. VBIAerSal2987_2600.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	A4SP35.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_2633-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_AERS4

Accession

Primary (citable) accession number: A4SP35

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program