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Protein

Cytidine deaminase

Gene

cdd

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Zinc; catalyticUniRule annotation1
Active sitei103Proton donorUniRule annotation1
Metal bindingi128Zinc; catalyticUniRule annotation1
Metal bindingi131Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
Ordered Locus Names:ASA_2410
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
Proteomesi
  • UP000000225 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000689461 – 293Cytidine deaminaseAdd BLAST293

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi382245.ASA_2410

Structurei

3D structure databases

ProteinModelPortaliA4SNI2
SMRiA4SNI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 166CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST120
Domaini186 – 293CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T42 Bacteria
COG0295 LUCA
HOGENOMiHOG000218617
KOiK01489
OMAiGHIDAQQ

Family and domain databases

HAMAPiMF_01558 Cyt_deam, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR013171 Cyd/dCyd_deaminase_Zn-bd
IPR016193 Cytidine_deaminase-like
IPR020797 Cytidine_deaminase_bacteria
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PF08211 dCMP_cyt_deam_2, 1 hit
SUPFAMiSSF53927 SSF53927, 2 hits
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

Sequencei

Sequence statusi: Complete.

A4SNI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRFAKPLD TLSAPLKAAL LPMLDNDFQA RFTPQQVATL KAATGLEDRA
60 70 80 90 100
LRLALLPLAA ACSVAPISKF FVGAIACGLS GTWYFGANME FAGQGLFHSV
110 120 130 140 150
HAEQSAISNA WLGGETGISE ITVNYTPCGH CRQFMNELST AKTLQVSLPD
160 170 180 190 200
DLSALQSFLP HSFGPADLDI TDALMSPQAH DELVLESEDP IWRAALAAAR
210 220 230 240 250
QSYAPYSQGY AAVALLFADG RLFCGRYAEN AAFNPSLPPM QMACAHAVLC
260 270 280 290
GEDLASIRRA VLLESKNGQI SQRDSAQSTL KALGSVELEY QAV
Length:293
Mass (Da):31,363
Last modified:May 15, 2007 - v1
Checksum:iB191CCD86223D363
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA Translation: ABO90454.1
RefSeqiWP_005310793.1, NC_009348.1

Genome annotation databases

EnsemblBacteriaiABO90454; ABO90454; ASA_2410
GeneIDi4995111
KEGGiasa:ASA_2410

Similar proteinsi

Entry informationi

Entry nameiCDD_AERS4
AccessioniPrimary (citable) accession number: A4SNI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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