A4SNH3 (ARAA_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	ASA_2399

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	L-arabinose isomerase HAMAP MF_00519		PRO_0000312598
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	350	1	Manganese By similarity
	Metal binding	449	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4SNH3-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 8D59CB6DEC75FF30	FASTA	499	55,297
	10 20 30 40 50 60 MEFMKQLEVW FLVGSQHLYS ATTLKQVADH AHTMTSQLNE GAGLPIKIVL KPTGTTLDEI 70 80 90 100 110 120 SSVARDANHS EQCVGLMVWM HTFSPAKMWI PALSQLQKPL LQFHTQFNRD LPWSEIDMDF 130 140 150 160 170 180 MNLNQTAHGG REFGFMGARL RLPRTVVVGH WQDEEAWSKI GNWMRIAAAI HDSRHLKIAR 190 200 210 220 230 240 FGDNMRNVAV TEGDKIEAQI QFGYQVNYHP VGDLVKIIDA VPAADIEALL AEYEQSYTLT 250 260 270 280 290 300 EAVQAGGPLR ASLYEAARQE LGMKKFLTEG GFGAFTTTFE DLHGLHQLPG LACQRLMQQG 310 320 330 340 350 360 FGFGAEGDWK TAALLRTIKV MGTGLAGGTS FMEDYTYHLE AGNNLVLGSH MLEVCPSIAA 370 380 390 400 410 420 DKPVLDAQHL GIGKKADPAR LLFAAPAGKA VNASLIDMGN RFRLVVNQLE VVDLPEAMPK 430 440 450 460 470 480 LPVASALWKP LPSLQTSAEA WILAGAAHHS VFTQSVDIEQ LRTFADIMGI EFVVIDEHTR 490 IPALKETLRW NEVYYKICH

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO90445.1.
RefSeq	YP_001142193.1.
3D structure databases
ProteinModelPortal	A4SNH3.
SMR	A4SNH3. Positions 1-495.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SNH3.
Genome annotation databases
GeneID	4995100.
GenomeReviews	Gene locus ASA_2399 in contig CP000644_GR.
KEGG	asa:ASA_2399.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	A4SNH3.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_2399-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARAA_AERS4

Accession

Primary (citable) accession number: A4SNH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	May 15, 2007
Last modified:	August 10, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)