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A4SMK1 (A4SMK1_AERS4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH EMBL ABO90123.1
Synonyms:fabH1 HAMAP MF_01815
Ordered Locus Names:ASA_2056
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region247 – 2515ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2461 By similarity HAMAP MF_01815
Active site2761 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A4SMK1 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 64118343920CF54C

FASTA31933,615
        10         20         30         40         50         60 
MHSKILGTGS YLPSSVRTNA DLEQMVETSD EWIVERTGIR ERRIAVADET VATLSHQAAL 

        70         80         90        100        110        120 
RALEAAGLTA VDLDMIVLAT TSAENAFPAA ACELQGLLGV PGIPAFDVAA ACAGFTYALS 

       130        140        150        160        170        180 
IADQFVKSGA ARHVLVVGAD VLSRMCDPQD RGTIILFGDG AGAVIVGANE TPGILSTHLH 

       190        200        210        220        230        240 
ADGRYGDLLK LPHPRRGMPG TELEAYMYMK GNDVFKVAVT RLSEIVTETL AAAGIAPSEL 

       250        260        270        280        290        300 
DWLVPHQANF RIISATAKKL GMSLDKVVLT LDKHGNTSAA SVPIAFDEGV RDGRIKPGQL 

       310 
VLLEAFGGGF AWGSALIRL

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References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000644 Genomic DNA. Translation: ABO90123.1.
RefSeqYP_001141871.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SMK1.
SMRA4SMK1. Positions 1-319.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4SMK1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4997525.
GenomeReviewsGene locus ASA_2056 in contig CP000644_GR.
KEGGasa:ASA_2056.
PATRIC20790451. VBIAerSal2987_2021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMARILNFLA.
PhylomeDBA4SMK1.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4SMK1_AERS4
AccessionPrimary (citable) accession number: A4SMK1
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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