Reviewed, UniProtKB/Swiss-Prot A4SM83 (AROC_AERS4)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	ASA_1932

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Chorismate synthase HAMAP MF_00300		PRO_0000322382

Sequences

	Sequence		Length	Mass (Da)
	A4SM83-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: C8D69D2876CAC985	FASTA	362	39,048
	10 20 30 40 50 60 MAGNSFGQLF RVTTFGESHG LALGAVVDGC PPGLEISEAD LQIDLDRRKP GTSRYTTPRR 70 80 90 100 110 120 EPDEVKILSG VFEGRTTGTS IGLLIENTDQ RSKDYSDIKD VFRPGHADYT YHQKYGQRDY 130 140 150 160 170 180 RGGGRSSARE TAMRVAAGAI AKKYLKQMHG IEITGFLSQL GPIKAEGFDA AQIEQNPFFF 190 200 210 220 230 240 PDAGKLEELD QYMRDLKKEG NSVGAKVQVI ATKVPVGLGE PVFDRLDADI AHAMMGINAV 250 260 270 280 290 300 KGVEIGDGFA VVEQKGSEHR DEMTPAGFAS NHAGGILGGI SSGQDIVVSM ALKPTSSITV 310 320 330 340 350 360 PGKTINTEGE AIEMITKGRH DPCVGIRAVP IAEAMLALVL MDHLLRHRAQ NQGVMTQTPQ LR

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO90005.1.
RefSeq	YP_001141753.1.
3D structure databases
SMR	A4SM83. Positions 4-353.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SM83.
Genome annotation databases
GeneID	4996783.
GenomeReviews	Gene locus ASA_1932 in contig CP000644_GR.
KEGG	asa:ASA_1932.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	A4SM83.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_AERS4

Accession

Primary (citable) accession number: A4SM83

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 15, 2007
Last modified:	February 9, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)