A4SM13 (AROA_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	ASA_1859

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012406

Sequences

	Sequence		Length	Mass (Da)
	A4SM13 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: F1601277F749D486	FASTA	427	46,247
	10 20 30 40 50 60 MNSLRLEPIS RVAGEVNLPG SKSVSNRALL LAALARGTTR LTNLLDSDDI RHMLAALTQL 70 80 90 100 110 120 GVKYKLSADK TECTVHGLGR SFAVSAPVNL FLGNAGTAMR PLCAALCLGS GEYMLGGEPR 130 140 150 160 170 180 MEERPIGHLV DALREAGAHI QYLKKDGYPP LVVDAKGLWG GDVHVDGSVS SQFLTAFLMA 190 200 210 220 230 240 APMAAGDTRI HIKGELVSKP YIDITLHIMK QFGVVIEHDN YKLFYIKGNQ SYVSPGDFLV 250 260 270 280 290 300 EGDASSASYF LAAGAIKGKV RVTGIGKHSI QGDIHFADVL ERMGARITWG DDFIEAEQGP 310 320 330 340 350 360 LHGVDMDMNH IPDAAMTIAV AALFAEGPTS IRNIYNWRVK ETDRLHAMAT ELRKLGVEVE 370 380 390 400 410 420 EGHDFITVTP PTQLKHAEID TYNDHRIAMC FSLVALSDIA VTINDPGCTS KTFPDYFDKL ASVSQAV

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO89935.1.
RefSeq	YP_001141683.1. NC_009348.1.
3D structure databases
ProteinModelPortal	A4SM13.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SM13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4997369.
GenomeReviews	Gene locus ASA_1859 in contig CP000644_GR.
KEGG	asa:ASA_1859.
PATRIC	20790092. VBIAerSal2987_1842.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	A4SM13.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_1859-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_AERS4

Accession

Primary (citable) accession number: A4SM13

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program