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A4SK25 (AROB_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:ASA_1126
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593593-dehydroquinate synthase HAMAP MF_00110
PRO_1000094448

Sequences

Sequence LengthMass (Da)Tools
A4SK25 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 7BD76CC584C081B0

FASTA35939,159
        10         20         30         40         50         60 
MERLKVELGE RSYPIEIAAG LLQHAEVLTQ TIKGKRVMIV TNTVVAPLYL ERIIQLLSGF 

        70         80         90        100        110        120 
QVEHLILPDG EAYKTLATFE RIMSALLETN HGRDTTLIAL GGGVIGDVVG FAAASYQRGI 

       130        140        150        160        170        180 
PFIQVPTTLL SQVDSSVGGK TAVNHPLGKN MIGAFYQPKH VVIDTECLKT LPAREFAAGM 

       190        200        210        220        230        240 
AEVIKYGIIW DAEFFSWLET NMSRLQALEP AALAYAIRRC CEIKADVVTQ DETEHGVRAL 

       250        260        270        280        290        300 
LNLGHTFGHA IEAEKGYGNW LHGEAVAAGM MMAASTAEAR GDLDARQLAR IRDLLLAANL 

       310        320        330        340        350 
PIQAPADMDF SAFIRHMRRD KKVLEGKLRL VLPVGIGHAQ VVADVSDDEL LAVIESGRE

« Hide

References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000644 Genomic DNA. Translation: ABO89247.1.
RefSeqYP_001140995.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SK25.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4SK25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4995527.
GenomeReviewsGene locus ASA_1126 in contig CP000644_GR.
KEGGasa:ASA_1126.
PATRIC20788616. VBIAerSal2987_1124.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBA4SK25.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycASAL382245:ASA_1126-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_AERS4
AccessionPrimary (citable) accession number: A4SK25
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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