Reviewed, UniProtKB/Swiss-Prot A4SK25 (AROB_AERS4)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	ASA_1126

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094448

Sequences

	Sequence		Length	Mass (Da)
	A4SK25-1 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 7BD76CC584C081B0	FASTA	359	39,159
	10 20 30 40 50 60 MERLKVELGE RSYPIEIAAG LLQHAEVLTQ TIKGKRVMIV TNTVVAPLYL ERIIQLLSGF 70 80 90 100 110 120 QVEHLILPDG EAYKTLATFE RIMSALLETN HGRDTTLIAL GGGVIGDVVG FAAASYQRGI 130 140 150 160 170 180 PFIQVPTTLL SQVDSSVGGK TAVNHPLGKN MIGAFYQPKH VVIDTECLKT LPAREFAAGM 190 200 210 220 230 240 AEVIKYGIIW DAEFFSWLET NMSRLQALEP AALAYAIRRC CEIKADVVTQ DETEHGVRAL 250 260 270 280 290 300 LNLGHTFGHA IEAEKGYGNW LHGEAVAAGM MMAASTAEAR GDLDARQLAR IRDLLLAANL 310 320 330 340 350 PIQAPADMDF SAFIRHMRRD KKVLEGKLRL VLPVGIGHAQ VVADVSDDEL LAVIESGRE

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449." Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000644 Genomic DNA. Translation: ABO89247.1.
RefSeq	YP_001140995.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A4SK25.
Genome annotation databases
GeneID	4995527.
GenomeReviews	Gene locus ASA_1126 in contig CP000644_GR.
KEGG	asa:ASA_1126.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LGEVIKY.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_AERS4

Accession

Primary (citable) accession number: A4SK25

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 15, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)