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A4SJW8

- SYL_AERS4

UniProt

A4SJW8 - SYL_AERS4

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASAL382245:GJJN-1063-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ASA_1068
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000225: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligasePRO_1000009287Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi382245.ASA_1068.

Structurei

3D structure databases

ProteinModelPortaliA4SJW8.
SMRiA4SJW8. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SJW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYVPQSI EPAVQKHWDA KKTFKAVEKV DKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRLNG KNVLQPIGWD AFGLPAENAA VKNNTAPAPW
110 120 130 140 150
TYENIEYMKN QLKMLGLGYD WDRELATCKP DYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTSSVNWCP NDMTVLANEQ VVDNCCWRCD TPVEQKEIPQ WFIKITDYAE
210 220 230 240 250
ELLNDIDNLE GWPEMVKTMQ RNWIGRSEGV NISFAIEGQA EQLEVYTTRP
260 270 280 290 300
DTFMGVTYVG IAAGHPLALQ AAATNPGLAA FIEECKNTKV AEAELATMEK
310 320 330 340 350
KGMATGLYAI HPLDGRKVPV WVANFVLMNY GTGAVMAVPG HDQRDHEFAT
360 370 380 390 400
KYGLDIKAVI KPADGEVDVS DAAYTEKGVL FASGEFDGLD FQGAFDAIAN
410 420 430 440 450
KLEALGHGKR TVNFRLRDWG VSRQRYWGAP IPMLTLADGT VVPTPEDQLP
460 470 480 490 500
VLLPEDVVMD GIQSPIKADA EWAKTTYNGQ EAFRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPDYDKG MLDPAAANHW LPVDQYIGGI EHACMHLLYA RFFHKLLRDA
560 570 580 590 600
GLVNSDEPFK RLLCQGMVLA DAFYYKDEKG GNVWVSPTDV KVERDEKGRI
610 620 630 640 650
TKAIDNDGRE VIHSGMTKMS KSKNNGIDPQ LMVERYGADT VRLFMMFASP
660 670 680 690 700
AEMTLEWSDS GVEGAQRFLR RLWRLTFEHV SAGAVPALDV AALTSEQKAV
710 720 730 740 750
RRELHKTIAK VSDDVGRRQT FNTAIAAIME LMNNLAKLGS DEQDRALMQE
760 770 780 790 800
ALETVVVMLS PITPHIGFEL WKMLGKGDDV DHATWPVADE AAMVETEKLV
810 820 830 840 850
VVQINGKMRG KLTVPAEISQ ADVEKLAMAD ASVQKFTDGL TVRKVIYVPG

KLLNIVAN
Length:858
Mass (Da):96,439
Last modified:May 15, 2007 - v1
Checksum:i4D1851864482DA11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO89190.1.
RefSeqiYP_001140938.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO89190; ABO89190; ASA_1068.
GeneIDi4998256.
KEGGiasa:ASA_1068.
PATRICi20788496. VBIAerSal2987_1064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000644 Genomic DNA. Translation: ABO89190.1 .
RefSeqi YP_001140938.1. NC_009348.1.

3D structure databases

ProteinModelPortali A4SJW8.
SMRi A4SJW8. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382245.ASA_1068.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO89190 ; ABO89190 ; ASA_1068 .
GeneIDi 4998256.
KEGGi asa:ASA_1068.
PATRICi 20788496. VBIAerSal2987_1064.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ASAL382245:GJJN-1063-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
    Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
    BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A449.

Entry informationi

Entry nameiSYL_AERS4
AccessioniPrimary (citable) accession number: A4SJW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3