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A4SJW8

- SYL_AERS4

UniProt

A4SJW8 - SYL_AERS4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASAL382245:GJJN-1063-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ASA_1068
    OrganismiAeromonas salmonicida (strain A449)
    Taxonomic identifieri382245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000225: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Leucine--tRNA ligasePRO_1000009287Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi382245.ASA_1068.

    Structurei

    3D structure databases

    ProteinModelPortaliA4SJW8.
    SMRiA4SJW8. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4SJW8-1 [UniParc]FASTAAdd to Basket

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    MQEQYVPQSI EPAVQKHWDA KKTFKAVEKV DKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VISRYQRLNG KNVLQPIGWD AFGLPAENAA VKNNTAPAPW 100
    TYENIEYMKN QLKMLGLGYD WDRELATCKP DYYRWEQWFF TKLYEKGLVY 150
    KKTSSVNWCP NDMTVLANEQ VVDNCCWRCD TPVEQKEIPQ WFIKITDYAE 200
    ELLNDIDNLE GWPEMVKTMQ RNWIGRSEGV NISFAIEGQA EQLEVYTTRP 250
    DTFMGVTYVG IAAGHPLALQ AAATNPGLAA FIEECKNTKV AEAELATMEK 300
    KGMATGLYAI HPLDGRKVPV WVANFVLMNY GTGAVMAVPG HDQRDHEFAT 350
    KYGLDIKAVI KPADGEVDVS DAAYTEKGVL FASGEFDGLD FQGAFDAIAN 400
    KLEALGHGKR TVNFRLRDWG VSRQRYWGAP IPMLTLADGT VVPTPEDQLP 450
    VLLPEDVVMD GIQSPIKADA EWAKTTYNGQ EAFRETDTFD TFMESSWYYA 500
    RYCSPDYDKG MLDPAAANHW LPVDQYIGGI EHACMHLLYA RFFHKLLRDA 550
    GLVNSDEPFK RLLCQGMVLA DAFYYKDEKG GNVWVSPTDV KVERDEKGRI 600
    TKAIDNDGRE VIHSGMTKMS KSKNNGIDPQ LMVERYGADT VRLFMMFASP 650
    AEMTLEWSDS GVEGAQRFLR RLWRLTFEHV SAGAVPALDV AALTSEQKAV 700
    RRELHKTIAK VSDDVGRRQT FNTAIAAIME LMNNLAKLGS DEQDRALMQE 750
    ALETVVVMLS PITPHIGFEL WKMLGKGDDV DHATWPVADE AAMVETEKLV 800
    VVQINGKMRG KLTVPAEISQ ADVEKLAMAD ASVQKFTDGL TVRKVIYVPG 850
    KLLNIVAN 858
    Length:858
    Mass (Da):96,439
    Last modified:May 15, 2007 - v1
    Checksum:i4D1851864482DA11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000644 Genomic DNA. Translation: ABO89190.1.
    RefSeqiWP_005317327.1. NC_009348.1.
    YP_001140938.1. NC_009348.1.

    Genome annotation databases

    EnsemblBacteriaiABO89190; ABO89190; ASA_1068.
    GeneIDi4998256.
    KEGGiasa:ASA_1068.
    PATRICi20788496. VBIAerSal2987_1064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000644 Genomic DNA. Translation: ABO89190.1 .
    RefSeqi WP_005317327.1. NC_009348.1.
    YP_001140938.1. NC_009348.1.

    3D structure databases

    ProteinModelPortali A4SJW8.
    SMRi A4SJW8. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382245.ASA_1068.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO89190 ; ABO89190 ; ASA_1068 .
    GeneIDi 4998256.
    KEGGi asa:ASA_1068.
    PATRICi 20788496. VBIAerSal2987_1064.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ASAL382245:GJJN-1063-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
      Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
      BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A449.

    Entry informationi

    Entry nameiSYL_AERS4
    AccessioniPrimary (citable) accession number: A4SJW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3