Malate dehydrogenase - Aeromonas salmonicida (strain A449)

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Reviewed, UniProtKB/Swiss-Prot A4SIV0 (MDH_AERS4)

Last modified June 16, 2009. Version 13. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Malate dehydrogenase
EC=1.1.1.37

Gene names

Name:	mdh
Ordered Locus Names:	ASA_0659

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.
Catalytic activity	(S)-malate + NAD⁺ = oxaloacetate + NADH. HAMAP MF_01516
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

311

Malate dehydrogenase HAMAP MF_01516

PRO_0000294293

Regions

Nucleotide binding

7

NAD By similarity

Nucleotide binding

3

NAD By similarity

Sites

Active site

1

Proton acceptor By similarity

Binding site

1

NAD By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

NAD By similarity

Binding site

1

Substrate By similarity

Binding site

1

Substrate By similarity

Binding site

1

NAD By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A4SIV0-1 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: EC37D0AF9C8150B3
Show »

311

32,139

        10         20         30         40         50         60 
MKVAVLGAAG GIGQALALLL KNRLPAGSEL SLYDIAPVTP GVAVDLSHIP TDVKVKGFCG 

        70         80         90        100        110        120 
EDPSPALVGA DVVLISAGVA RKPGMDRSDL FNINPGIVKN LVEKCAASCP KALIGIITNP 

       130        140        150        160        170        180 
VNTTVAIAAE VLKKAGVYDK RRLFGVTTLD VIRAETFVAD AKGLNVDKVR VNVIGGHSGV 

       190        200        210        220        230        240 
TILPLLSQIE GASFSAEEVA AMTKRIQNAG TEVVEAKAGG GSATLSMGQA ACRFGLSLIK 

       250        260        270        280        290        300 
GLQGEANVIE CAYVEGDGKH ATFFAQPILL GKNGVETVLD YGKLSAFEQE AMEGMLATLK 

       310 
ADIQLGVEFV K

References

[1]

"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449."
Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CP000644 Genomic DNA. Translation: ABO88822.1.
RefSeq	YP_001140570.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4996474.
GenomeReviews	Gene locus ASA_0659 in contig CP000644_GR.
KEGG	asa:ASA_0659.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A4SIV0. MGWTTQE.
Family and domain databases
HAMAP	MF_01516. [Tree]
InterPro	IPR001557. L-lactate/malate_DH. IPR001236. Lactate/malate_DH. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_NAD-dep_euk_g_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11540:SF1. MDH_euk_g_bac. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
TIGRFAMs	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDH_AERS4

Accession

Primary (citable) accession number: A4SIV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	May 15, 2007
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents