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A4SIM6 (ARLY_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:ASA_0582
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Argininosuccinate lyase HAMAP MF_00006
PRO_1000000449

Sequences

Sequence LengthMass (Da)Tools
A4SIM6 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: BA5C4380DDD62A90

FASTA46150,210
        10         20         30         40         50         60 
MALWGGRFSQ GADSRFKQFN DSLRFDYRLA EQDIQGSMAW AKALVKVGVL TADEQGKLQQ 

        70         80         90        100        110        120 
AMEVLLASVQ QDPHQILNSD AEDIHSWVES QLIAAVGDLG KKLHTGRSRN DQVATDLKLW 

       130        140        150        160        170        180 
CKAQGELLLG SISALQAGLV ASARANQAAV LPGYTHLQRA QPVTFAHWAL AYVEMLERDY 

       190        200        210        220        230        240 
SRLQDALKRL DTSPLGCGAL AGTAYAIDRE ALALDMGFGG ATRNSLDSVS DRDHVVELMH 

       250        260        270        280        290        300 
VASLSMTHLS RFAEDLIFYN TGEAGFVELS DAVTSGSSLM PQKKNPDALE LIRGKTGRVV 

       310        320        330        340        350        360 
GAQMGMLMSL KALPLAYNKD MQEDKEGLFD ALDTWHDCLD MAALVLIDLK VNVERTKAAA 

       370        380        390        400        410        420 
QGGYANATEL ADYLVAKGIP FREAHHIVGE TVVYALEVKK PLEDLSLPEF QRFSPVIGED 

       430        440        450        460 
VYPNLELEAT LAKRVAKGGV ARELVDAALT AAEQWLAKWA G

« Hide

References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000644 Genomic DNA. Translation: ABO88748.1.
RefSeqYP_001140496.1. NC_009348.1.

3D structure databases

ProteinModelPortalA4SIM6.
SMRA4SIM6. Positions 3-457.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4SIM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4996911.
GenomeReviewsGene locus ASA_0582 in contig CP000644_GR.
KEGGasa:ASA_0582.
PATRIC20787488. VBIAerSal2987_0587.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBA4SIM6.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycASAL382245:ASA_0582-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_AERS4
AccessionPrimary (citable) accession number: A4SIM6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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