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A4SIM5

- ASSY_AERS4

UniProt

A4SIM5 - ASSY_AERS4

Protein

Argininosuccinate synthase

Gene

argG

Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei94 – 941CitrullineUniRule annotation
    Binding sitei99 – 991CitrullineUniRule annotation
    Binding sitei124 – 1241ATP; via amide nitrogenUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei130 – 1301AspartateUniRule annotation
    Binding sitei130 – 1301CitrullineUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei134 – 1341CitrullineUniRule annotation
    Binding sitei183 – 1831CitrullineUniRule annotation
    Binding sitei192 – 1921CitrullineUniRule annotation
    Binding sitei268 – 2681CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASAL382245:GJJN-577-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:ASA_0581
    OrganismiAeromonas salmonicida (strain A449)
    Taxonomic identifieri382245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
    ProteomesiUP000000225: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Argininosuccinate synthasePRO_0000321298Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi382245.ASA_0581.

    Structurei

    3D structure databases

    ProteinModelPortaliA4SIM5.
    SMRiA4SIM5. Positions 11-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4SIM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERSKMSGIN KIVLAYSGGL DTSAIIPWLK EHYDAEIIAF VADVGQERDD    50
    LEGIEQKAIA SGAVKCIVKD LREEFVKEYV YPTLKTGAVY EGTYLLGTSM 100
    ARPIIAKAMV EAALAEGADA ISHGCTGKGN DQVRFEGAVA ALAPQLKVIA 150
    PWRLWDMRSR EDLLAYLEAR DIPCKATLKK IYSRDANAWH ISTEGGELES 200
    TWNEPSEAVW QWTVSAEQAP NEPEYVKLTV AKGEVVAVDD QPLSPHQILT 250
    TLNERAGKHG VGRIDITENR MVGMKSRGCY ETPGGTVMVA ALRAVEELVL 300
    DRPTRAWREK LGAEFSHLVY DGRWFTPLCK AIVASANAIA EDLDGEVILK 350
    MYKGQVTAVQ KKSPNSLYSE DFATFGADEV YDQSHAEGFI RLYTLASRIR 400
    AMKEQHQAIG GDHTHG 416
    Length:416
    Mass (Da):45,832
    Last modified:May 15, 2007 - v1
    Checksum:i00594AB24BD9F952
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000644 Genomic DNA. Translation: ABO88747.1.
    RefSeqiYP_001140495.1. NC_009348.1.

    Genome annotation databases

    EnsemblBacteriaiABO88747; ABO88747; ASA_0581.
    GeneIDi4995922.
    KEGGiasa:ASA_0581.
    PATRICi20787486. VBIAerSal2987_0586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000644 Genomic DNA. Translation: ABO88747.1 .
    RefSeqi YP_001140495.1. NC_009348.1.

    3D structure databases

    ProteinModelPortali A4SIM5.
    SMRi A4SIM5. Positions 11-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 382245.ASA_0581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO88747 ; ABO88747 ; ASA_0581 .
    GeneIDi 4995922.
    KEGGi asa:ASA_0581.
    PATRICi 20787486. VBIAerSal2987_0586.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci ASAL382245:GJJN-577-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
      Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
      BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A449.

    Entry informationi

    Entry nameiASSY_AERS4
    AccessioniPrimary (citable) accession number: A4SIM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3