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A4SIM5

- ASSY_AERS4

UniProt

A4SIM5 - ASSY_AERS4

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Protein

Argininosuccinate synthase

Gene
argG, ASA_0581
Organism
Aeromonas salmonicida (strain A449)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei94 – 941Citrulline By similarity
Binding sitei99 – 991Citrulline By similarity
Binding sitei124 – 1241ATP; via amide nitrogen By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei130 – 1301Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei131 – 1311Aspartate By similarity
Binding sitei134 – 1341Citrulline By similarity
Binding sitei183 – 1831Citrulline By similarity
Binding sitei192 – 1921Citrulline By similarity
Binding sitei268 – 2681Citrulline By similarity
Binding sitei280 – 2801Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASAL382245:GJJN-577-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:ASA_0581
OrganismiAeromonas salmonicida (strain A449)
Taxonomic identifieri382245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas
ProteomesiUP000000225: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Argininosuccinate synthaseUniRule annotationPRO_0000321298Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi382245.ASA_0581.

Structurei

3D structure databases

ProteinModelPortaliA4SIM5.
SMRiA4SIM5. Positions 11-405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4SIM5-1 [UniParc]FASTAAdd to Basket

« Hide

MERSKMSGIN KIVLAYSGGL DTSAIIPWLK EHYDAEIIAF VADVGQERDD    50
LEGIEQKAIA SGAVKCIVKD LREEFVKEYV YPTLKTGAVY EGTYLLGTSM 100
ARPIIAKAMV EAALAEGADA ISHGCTGKGN DQVRFEGAVA ALAPQLKVIA 150
PWRLWDMRSR EDLLAYLEAR DIPCKATLKK IYSRDANAWH ISTEGGELES 200
TWNEPSEAVW QWTVSAEQAP NEPEYVKLTV AKGEVVAVDD QPLSPHQILT 250
TLNERAGKHG VGRIDITENR MVGMKSRGCY ETPGGTVMVA ALRAVEELVL 300
DRPTRAWREK LGAEFSHLVY DGRWFTPLCK AIVASANAIA EDLDGEVILK 350
MYKGQVTAVQ KKSPNSLYSE DFATFGADEV YDQSHAEGFI RLYTLASRIR 400
AMKEQHQAIG GDHTHG 416
Length:416
Mass (Da):45,832
Last modified:May 15, 2007 - v1
Checksum:i00594AB24BD9F952
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000644 Genomic DNA. Translation: ABO88747.1.
RefSeqiYP_001140495.1. NC_009348.1.

Genome annotation databases

EnsemblBacteriaiABO88747; ABO88747; ASA_0581.
GeneIDi4995922.
KEGGiasa:ASA_0581.
PATRICi20787486. VBIAerSal2987_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000644 Genomic DNA. Translation: ABO88747.1 .
RefSeqi YP_001140495.1. NC_009348.1.

3D structure databases

ProteinModelPortali A4SIM5.
SMRi A4SIM5. Positions 11-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 382245.ASA_0581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO88747 ; ABO88747 ; ASA_0581 .
GeneIDi 4995922.
KEGGi asa:ASA_0581.
PATRICi 20787486. VBIAerSal2987_0586.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci ASAL382245:GJJN-577-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
    Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
    BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A449.

Entry informationi

Entry nameiASSY_AERS4
AccessioniPrimary (citable) accession number: A4SIM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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