A4SIM2 (ARGC_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	ASA_0578

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010972
Sites
	Active site	156	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4SIM2 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: A10FBA35A0572798	FASTA	335	35,962
	10 20 30 40 50 60 MLNTVIVGAS GYAGAELAAL VQNHPQLKLF GLYVSAGSQD AHKRFSSLHP QWVGALDQPL 70 80 90 100 110 120 LPLDEDGMTR ILTQADLVLL ATAHEVSAEL APKFLAKGLP VFDLSGAFRV KDQQFYSSFY 130 140 150 160 170 180 GFTHENEQLL EQAAYGLAEW NSDAIAAAQL IAVPGCYPTA SLCALKPLQQ AGLIAEGWQP 190 200 210 220 230 240 IINAVSGVSG AGRKAAINTS FCEVSLSPYG TFNHRHQPEI SHHLGKEVLF QPHLGNYVRG 250 260 270 280 290 300 ILATIYVQMA DGVTPTQVDQ AFLKAYEGKP LVRLTGQMPS IRGVASTPYC DIAWQQQGNM 310 320 330 LVVVSAIDNL LKGAASQAMQ CINIKFGFDP ATGLI

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO88744.1.
RefSeq	YP_001140492.1. NC_009348.1.
3D structure databases
ProteinModelPortal	A4SIM2.
SMR	A4SIM2. Positions 1-335.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SIM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4998422.
GenomeReviews	Gene locus ASA_0578 in contig CP000644_GR.
KEGG	asa:ASA_0578.
PATRIC	20787480. VBIAerSal2987_0583.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	VCRIAVH.
PhylomeDB	A4SIM2.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_0578-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AERS4

Accession

Primary (citable) accession number: A4SIM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program