A4SHP8 (PYRB_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	ASA_0228

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301549

Sequences

	Sequence		Length	Mass (Da)
	A4SHP8 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: A35449D90ECCD956	FASTA	306	34,138
	10 20 30 40 50 60 MTNPLYKKHV ISISDLTRPD MELVVATAQR LKAEPDTRLL KDKLIASCFF EASTRTRLSF 70 80 90 100 110 120 ETAVQRLGGN IIGFADGGNT SAKKGETLAD SIKIIGSYSD AVVMRHPKEG AARLASEFSR 130 140 150 160 170 180 VPVINGGDGS NQHPTQTLLD LFSIHETQGK LDGLNVAFVG DLKYGRTVHS LAQALSLFNC 190 200 210 220 230 240 RFFFISPDAL AMPDYICEEL EEKGIRFSVH ETMEEVMPEL DILYMTRVQK ERFDETEYKH 250 260 270 280 290 300 MAAKFVLELA TLEGAKPTMK ILHPLPRVDE IDVAVDKTPY AYYFQQAENG VYARQALLAL VLNETV

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed: 18801193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO88420.1.
RefSeq	YP_001140168.1. NC_009348.1.
3D structure databases
ProteinModelPortal	A4SHP8.
SMR	A4SHP8. Positions 3-306.
ModBase	Search...
Protein-protein interaction databases
STRING	A4SHP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4998552.
GenomeReviews	Gene locus ASA_0228 in contig CP000644_GR.
KEGG	asa:ASA_0228.
PATRIC	20786748. VBIAerSal2987_0237.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	FKQSFYG.
PhylomeDB	A4SHP8.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	ASAL382245:ASA_0228-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_AERS4

Accession

Primary (citable) accession number: A4SHP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program