A4SHM8 (UPPP_AERS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA
Ordered Locus Names:	ASA_0206

Organism

Aeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]

Taxonomic identifier

382245 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas › Aeromonas salmonicida › Aeromonas salmonicida subsp. salmonicida

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000303018
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A4SHM8 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 8DF484EB2DC12D16	FASTA	271	29,417
	10 20 30 40 50 60 MTESYALFVA FVLGIVEGLT EFLPVSSTGH MIIVGHLLGF EGPKAATFEV VIQMGSILAV 70 80 90 100 110 120 VAVFWRRLFG LIGIHFGQKP PQDHATLSLV HIILGMLPAV IIGLGIHSWI KANLFGPETV 130 140 150 160 170 180 MYALVAGGIL LIIAEKFRPT VRSETLDDIS YKQAFGIGLF QCLALWPGFS RSGATISGGM 190 200 210 220 230 240 LMGISRQAAA EFSFILAVPM MVAASGLDLY KSRDLLSMAD FPMFAVGFIT AFVVAMIAIK 250 260 270 TFLALIRRLD FIPFAIYRFI VAFAVYLVFV A

References

[1]

"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen." Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L. BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A449.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000644 Genomic DNA. Translation: ABO88400.1.
RefSeq	YP_001140148.1. NC_009348.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	382245.ASA_0206.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABO88400; ABO88400; ASA_0206.
GeneID	4998793.
KEGG	asa:ASA_0206.
PATRIC	20786701. VBIAerSal2987_0214.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	PERENVT.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	ASAL382245:GJJN-204-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_AERS4

Accession

Primary (citable) accession number: A4SHM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program