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A4SHM8 (UPPP_AERS4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:ASA_0206
OrganismAeromonas salmonicida (strain A449) [Complete proteome] [HAMAP]
Taxonomic identifier382245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000303018

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane251 – 27121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4SHM8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 8DF484EB2DC12D16

FASTA27129,417
        10         20         30         40         50         60 
MTESYALFVA FVLGIVEGLT EFLPVSSTGH MIIVGHLLGF EGPKAATFEV VIQMGSILAV 

        70         80         90        100        110        120 
VAVFWRRLFG LIGIHFGQKP PQDHATLSLV HIILGMLPAV IIGLGIHSWI KANLFGPETV 

       130        140        150        160        170        180 
MYALVAGGIL LIIAEKFRPT VRSETLDDIS YKQAFGIGLF QCLALWPGFS RSGATISGGM 

       190        200        210        220        230        240 
LMGISRQAAA EFSFILAVPM MVAASGLDLY KSRDLLSMAD FPMFAVGFIT AFVVAMIAIK 

       250        260        270 
TFLALIRRLD FIPFAIYRFI VAFAVYLVFV A 

« Hide

References

[1]"The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen."
Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C., Brown L.L.
BMC Genomics 9:427-427(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000644 Genomic DNA. Translation: ABO88400.1.
RefSeqYP_001140148.1. NC_009348.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING382245.ASA_0206.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO88400; ABO88400; ASA_0206.
GeneID4998793.
KEGGasa:ASA_0206.
PATRIC20786701. VBIAerSal2987_0214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycASAL382245:GJJN-204-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_AERS4
AccessionPrimary (citable) accession number: A4SHM8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families